Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 1239368..1239924 Replicon chromosome
Accession NZ_CP045913
Organism Serratia proteamaculans strain 336X

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag GHV41_RS06090 Protein ID WP_153857944.1
Coordinates 1239634..1239924 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag GHV41_RS06085 Protein ID WP_153857943.1
Coordinates 1239368..1239646 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GHV41_RS06060 1234708..1235547 - 840 WP_153857938.1 MurR/RpiR family transcriptional regulator -
GHV41_RS06065 1235693..1237279 + 1587 WP_153857939.1 gamma-glutamyltransferase family protein -
GHV41_RS06070 1237305..1237496 + 192 WP_153857940.1 oxalurate catabolism protein HpxX -
GHV41_RS06075 1237493..1238893 + 1401 WP_153857941.1 AtzE family amidohydrolase -
GHV41_RS06080 1238896..1239282 + 387 WP_153857942.1 oxalurate catabolism protein HpxZ -
GHV41_RS06085 1239368..1239646 + 279 WP_153857943.1 ribbon-helix-helix protein, CopG family Antitoxin
GHV41_RS06090 1239634..1239924 + 291 WP_153857944.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GHV41_RS06095 1239934..1240818 - 885 WP_153857945.1 siderophore-interacting protein -
GHV41_RS06100 1240824..1242047 - 1224 WP_153857946.1 MFS transporter -
GHV41_RS06105 1242185..1243930 + 1746 WP_153857947.1 IucA/IucC family siderophore biosynthesis protein -
GHV41_RS06110 1243927..1244877 + 951 WP_153857948.1 acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11027.57 Da        Isoelectric Point: 7.2006

>T142970 WP_153857944.1 NZ_CP045913:1239634-1239924 [Serratia proteamaculans]
VPQLIWTPAALQDIQRLYRFLAEKDLNSAKRAVVTIRRSINILAHQPQVGRPIEEMDTEFREWPIDFGNSGYIALYRFDG
NTAVLLAVRHQSEAGY

Download         Length: 291 bp

>T142970 NZ_CP060914:c4422621-4422334 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTAAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10806.98 Da        Isoelectric Point: 5.2246

>AT142970 WP_153857943.1 NZ_CP045913:1239368-1239646 [Serratia proteamaculans]
MTSATSIKIDEQLKQRVQQIAATRQRSAHWIMREAIREYVEREEKREALRKDALQAWEAYQANGKHLSQEEANNWLADLE
KGDDTEIPECHN

Download         Length: 279 bp

>AT142970 NZ_CP060914:c4422347-4422045 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCAATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References