142969

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1028592..1029219 Replicon chromosome
Accession NZ_CP045913
Organism Serratia proteamaculans strain 336X

Toxin (Protein)


Gene name Hha Uniprot ID A0A2X2GU35
Locus tag GHV41_RS05110 Protein ID WP_012005558.1
Coordinates 1029016..1029219 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag GHV41_RS05105 Protein ID WP_004940312.1
Coordinates 1028592..1028960 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GHV41_RS05075 1024631..1024888 + 258 WP_012005564.1 type B 50S ribosomal protein L31 -
GHV41_RS05080 1024901..1025041 + 141 WP_153857805.1 type B 50S ribosomal protein L36 -
GHV41_RS05085 1025155..1026033 - 879 WP_153857806.1 metal ABC transporter substrate-binding protein -
GHV41_RS05090 1026059..1026916 - 858 WP_153857807.1 metal ABC transporter permease -
GHV41_RS05095 1026913..1027626 - 714 WP_153857808.1 ABC transporter ATP-binding protein -
GHV41_RS05100 1028103..1028429 + 327 WP_153860853.1 hypothetical protein -
GHV41_RS05105 1028592..1028960 + 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
GHV41_RS05110 1029016..1029219 + 204 WP_012005558.1 hemolysin expression modulator Hha Toxin
GHV41_RS05115 1029296..1030228 - 933 WP_153857809.1 LysR family transcriptional regulator -
GHV41_RS05120 1030366..1032153 + 1788 WP_153857810.1 adenine deaminase -
GHV41_RS05125 1032193..1033542 + 1350 WP_153857811.1 NCS2 family permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8101.45 Da        Isoelectric Point: 6.9770

>T142969 WP_012005558.1 NZ_CP045913:1029016-1029219 [Serratia proteamaculans]
MTKIDYLMRLRKCTTIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTAVWKFVR

Download         Length: 204 bp

>T142969 NZ_CP060914:4042366-4042644 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAAGTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT142969 WP_004940312.1 NZ_CP045913:1028592-1028960 [Serratia proteamaculans]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT142969 NZ_CP060914:4042103-4042363 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X2GU35

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References