Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 507667..508220 Replicon chromosome
Accession NZ_CP045913
Organism Serratia proteamaculans strain 336X

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag GHV41_RS02435 Protein ID WP_115182894.1
Coordinates 507667..507981 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A379YKU0
Locus tag GHV41_RS02440 Protein ID WP_012005987.1
Coordinates 507984..508220 (-) Length 79 a.a.

Genomic Context

GHV41_RS02420GHV41_RS02425GHV41_RS02430GHV41_RS02415GHV41_RS02435GHV41_RS02440GHV41_RS02445GHV41_RS02450GHV41_RS02455
Location: 504702..505619 (918 bp)
Type: Others
Protein ID: WP_153857425.1
Location: 505646..506773 (1128 bp)
Type: Others
Protein ID: WP_012005990.1
Location: 506788..507630 (843 bp)
Type: Others
Protein ID: WP_153857426.1
Location: 503438..504595 (1158 bp)
Type: Others
Protein ID: WP_153857424.1
Location: 507667..507981 (315 bp)
Type: Toxin
Protein ID: WP_115182894.1
Location: 507984..508220 (237 bp)
Type: Antitoxin
Protein ID: WP_012005987.1
Location: 508818..509726 (909 bp)
Type: Others
Protein ID: WP_206194501.1
Location: 509736..510656 (921 bp)
Type: Others
Protein ID: WP_153857427.1
Location: 510707..512245 (1539 bp)
Type: Others
Protein ID: WP_153857428.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GHV41_RS02415503438..504595-1158WP_153857424.1YbfB/YjiJ family MFS transporter-
GHV41_RS02420504702..505619+918WP_153857425.1LysR family transcriptional regulator-
GHV41_RS02425505646..506773+1128WP_012005990.1S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase-
GHV41_RS02430506788..507630+843WP_153857426.1S-formylglutathione hydrolase-
GHV41_RS02435507667..507981-315WP_115182894.1CcdB family proteinToxin
GHV41_RS02440507984..508220-237WP_012005987.1type II toxin-antitoxin system CcdA family antitoxinAntitoxin
GHV41_RS02445508818..509726-909WP_206194501.1glutathione ABC transporter permease GsiD-
GHV41_RS02450509736..510656-921WP_153857427.1glutathione ABC transporter permease GsiC-
GHV41_RS02455510707..512245-1539WP_153857428.1glutathione ABC transporter substrate-binding protein GsiB-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11678.63 Da        Isoelectric Point: 5.0772

>T142968 WP_115182894.1 NZ_CP045913:c507981-507667 [Serratia proteamaculans]
MQFTVYANTGKSVVYPLLLDVTSDIIGQLNRRVVIPLLPIEKYPGNTRPERLIPLVRLVDDKEYAVMTHEMASIPVRALG
AEFCDATQYRTEVKAAIDFLLDGI

Download         Length: 315 bp

>T142968 NZ_CP060914:3805863-3806405 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9108.19 Da        Isoelectric Point: 6.7184

>AT142968 WP_012005987.1 NZ_CP045913:c508220-507984 [Serratia proteamaculans]
MPVKQRTTQSVTMTVERSLLSRAREAGINLSATLNAALDAELRQHEMRKWKEDNREAIEALNRFHDEHGCFSDEYRTF

Download         Length: 237 bp

>AT142968 NZ_CP060914:3805568-3805879 [Escherichia coli]
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A379YKU0

References