Detailed information of TA system TA142968

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 507667..508220
• Replicon: chromosome
• Accession: NZ_CP045913
• Organism: Serratia proteamaculans strain 336X

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: GHV41_RS02435
• Protein ID: WP_115182894.1
• Coordinates: 507667..507981 (-)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: A0A379YKU0
• Locus tag: GHV41_RS02440
• Protein ID: WP_012005987.1
• Coordinates: 507984..508220 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GHV41_RS02415	503438..504595	-	1158	WP_153857424.1	YbfB/YjiJ family MFS transporter	-
GHV41_RS02420	504702..505619	+	918	WP_153857425.1	LysR family transcriptional regulator	-
GHV41_RS02425	505646..506773	+	1128	WP_012005990.1	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase	-
GHV41_RS02430	506788..507630	+	843	WP_153857426.1	S-formylglutathione hydrolase	-
GHV41_RS02435	507667..507981	-	315	WP_115182894.1	CcdB family protein	Toxin
GHV41_RS02440	507984..508220	-	237	WP_012005987.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
GHV41_RS02445	508818..509726	-	909	WP_206194501.1	glutathione ABC transporter permease GsiD	-
GHV41_RS02450	509736..510656	-	921	WP_153857427.1	glutathione ABC transporter permease GsiC	-
GHV41_RS02455	510707..512245	-	1539	WP_153857428.1	glutathione ABC transporter substrate-binding protein GsiB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-103)

Antitoxin

• Post-segregation antitoxin CcdA (9-78)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 11678.63 Da
• Isoelectric Point: 5.0772

>T142968 WP_115182894.1 NZ_CP045913:c507981-507667 [Serratia proteamaculans]
MQFTVYANTGKSVVYPLLLDVTSDIIGQLNRRVVIPLLPIEKYPGNTRPERLIPLVRLVDDKEYAVMTHEMASIPVRALG
AEFCDATQYRTEVKAAIDFLLDGI

Nucleotide

• Length: 315 bp

>T142968 NZ_CP060914:3805863-3806405 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9108.19 Da
• Isoelectric Point: 6.7184

>AT142968 WP_012005987.1 NZ_CP045913:c508220-507984 [Serratia proteamaculans]
MPVKQRTTQSVTMTVERSLLSRAREAGINLSATLNAALDAELRQHEMRKWKEDNREAIEALNRFHDEHGCFSDEYRTF

Nucleotide

• Length: 237 bp

>AT142968 NZ_CP060914:3805568-3805879 [Escherichia coli]
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Structures

Antitoxin

• AlphaFold DB: A0A379YKU0