Detailed information of TA system TA142954

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2901021..2901649
• Replicon: chromosome
• Accession: NZ_CP045875
• Organism: Heliorestis convoluta strain HH

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: FTV88_RS13825
• Protein ID: WP_153726151.1
• Coordinates: 2901021..2901374 (-)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: FTV88_RS13830
• Protein ID: WP_151620922.1
• Coordinates: 2901380..2901649 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FTV88_RS13795	2896134..2896865	-	732	WP_153726145.1	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB	-
FTV88_RS13800	2896829..2897344	-	516	WP_153726146.1	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE	-
FTV88_RS13805	2897441..2897872	-	432	WP_162008063.1	response regulator	-
FTV88_RS13810	2897984..2899132	-	1149	WP_153726148.1	amidohydrolase	-
FTV88_RS13815	2899148..2900149	-	1002	WP_162008064.1	asparaginase	-
FTV88_RS13820	2900236..2900967	-	732	WP_162008065.1	gamma-glutamyl-gamma-aminobutyrate hydrolase family protein	-
FTV88_RS13825	2901021..2901374	-	354	WP_153726151.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
FTV88_RS13830	2901380..2901649	-	270	WP_151620922.1	ribbon-helix-helix protein, CopG family	Antitoxin
FTV88_RS13835	2901767..2902918	-	1152	WP_153726152.1	alanine racemase	-
FTV88_RS13840	2902935..2903390	-	456	WP_153726669.1	CBS domain-containing protein	-
FTV88_RS13845	2903419..2904966	-	1548	WP_153726153.1	NAD(P)H-hydrate dehydratase	-
FTV88_RS13850	2904957..2905391	-	435	WP_162008067.1	holo-ACP synthase	-
FTV88_RS13855	2905448..2905948	-	501	WP_153726155.1	chemotaxis protein CheW	-
FTV88_RS13860	2905948..2906421	-	474	WP_153726156.1	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (2-114)

Antitoxin

• Ribbon-helix-helix protein, CopG (6-41)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 12853.79 Da
• Isoelectric Point: 5.7185

>T142954 WP_153726151.1 NZ_CP045875:c2901374-2901021 [Heliorestis convoluta]
MAHIRRGEVYYAELNPVVGSEQGGTRPVLIIQNDIGNQYSPTTIVAAITSQISKAKLPTHVEVPSSRSGLDRDSVVLLEQ
IRTIDKTRLREKIGLLDEDMMSKVAQALEISLGLIDL

Nucleotide

• Length: 354 bp

>T142954 NZ_CP060914:931223-931606 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCAGGAGTCGAAACGATGCAACTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10567.44 Da
• Isoelectric Point: 8.5839

>AT142954 WP_151620922.1 NZ_CP045875:c2901649-2901380 [Heliorestis convoluta]
VPDLKRIQVTLPETLLTELDRVLMAEKMNRSQLIREAVNLYMIEHKRKVLRDQMRRGYIEMARINLELALEGFTAEVDVE
RLFEARLAR

Nucleotide

• Length: 270 bp

>AT142954 NZ_CP060914:930765-931133 [Escherichia coli]
GTGTCAGACACATTCTCCGGGACAACGCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGTACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTACAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGAACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCAGT
GAACTGAATCCCCACCGTCAGAATACCGTCACGCTGTATGTTAAAGGGCTGACCTGCCATGCGGACACCCTCGGCAGCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA