Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2845721..2846352 Replicon chromosome
Accession NZ_CP045870
Organism Klebsiella aerogenes strain Y1

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H3FL31
Locus tag GIY00_RS13680 Protein ID WP_015703741.1
Coordinates 2845721..2845996 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0H3FNK6
Locus tag GIY00_RS13685 Protein ID WP_015703740.1
Coordinates 2845993..2846352 (+) Length 120 a.a.

Genomic Context

GIY00_RS13660GIY00_RS13670GIY00_RS13680GIY00_RS13685GIY00_RS13665GIY00_RS13675GIY00_RS13690GIY00_RS13695GIY00_RS13700GIY00_RS13705GIY00_RS13710
Location: 2840949..2841284 (336 bp)
Type: Others
Protein ID: WP_015703743.1
Location: 2843077..2844270 (1194 bp)
Type: Others
Protein ID: WP_032709350.1
Location: 2845721..2845996 (276 bp)
Type: Toxin
Protein ID: WP_015703741.1
Location: 2845993..2846352 (360 bp)
Type: Antitoxin
Protein ID: WP_015703740.1
Location: 2841350..2842846 (1497 bp)
Type: Others
Protein ID: WP_015369272.1
Location: 2844311..2845324 (1014 bp)
Type: Others
Protein ID: WP_015369274.1
Location: 2846380..2846781 (402 bp)
Type: Others
Protein ID: WP_032709347.1
Location: 2846769..2847560 (792 bp)
Type: Others
Protein ID: WP_032709345.1
Location: 2847557..2848321 (765 bp)
Type: Others
Protein ID: WP_015703737.1
Location: 2848321..2849154 (834 bp)
Type: Others
Protein ID: WP_015369278.1
Location: 2849151..2850095 (945 bp)
Type: Others
Protein ID: WP_015703735.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GIY00_RS136602840949..2841284+336WP_015703743.1universal stress protein UspB-
GIY00_RS136652841350..2842846-1497WP_015369272.1inorganic phosphate transporter PitA-
GIY00_RS136702843077..2844270+1194WP_032709350.1NAD(P)/FAD-dependent oxidoreductase-
GIY00_RS136752844311..2845324-1014WP_015369274.1magnesium transporter-
GIY00_RS136802845721..2845996+276WP_015703741.1type II toxin-antitoxin system HicA family toxinToxin
GIY00_RS136852845993..2846352+360WP_015703740.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
GIY00_RS136902846380..2846781-402WP_032709347.1nickel-responsive transcriptional regulator NikR-
GIY00_RS136952846769..2847560-792WP_032709345.1nickel import ATP-binding protein NikE-
GIY00_RS137002847557..2848321-765WP_015703737.1nickel import ATP-binding protein NikD-
GIY00_RS137052848321..2849154-834WP_015369278.1nickel ABC transporter permease subunit NikC-
GIY00_RS137102849151..2850095-945WP_015703735.1nickel ABC transporter permease subunit NikB-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10258.89 Da        Isoelectric Point: 10.4888

>T142940 WP_015703741.1 NZ_CP045870:2845721-2845996 [Klebsiella aerogenes]
MEQQVLSLRKKQRNTLEQLFKTPVPQGIKWADIESLIKALGGEIKEGRGSRCKFLLNHSIASFHRPHPSPDTDKGAVESV
RDWLITIGVKP

Download         Length: 276 bp

>T142940 NZ_CP060908:c1877925-1877551 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCCA
CAACTACAGAACGGTGAACAATATCACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13305.02 Da        Isoelectric Point: 4.3472

>AT142940 WP_015703740.1 NZ_CP045870:2845993-2846352 [Klebsiella aerogenes]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQQEGEISLQEYLADCREAGIEPYAQPEKLKT
FTLRYPESFGERLSSAAAEEQVSVNTWILETLNERLKQA

Download         Length: 360 bp

>AT142940 NZ_CP060908:c1878383-1878015 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0H3FL31

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0H3FNK6

References