Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2845721..2846352 Replicon chromosome
Accession NZ_CP045870
Organism Klebsiella aerogenes strain Y1

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H3FL31
Locus tag GIY00_RS13680 Protein ID WP_015703741.1
Coordinates 2845721..2845996 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0H3FNK6
Locus tag GIY00_RS13685 Protein ID WP_015703740.1
Coordinates 2845993..2846352 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GIY00_RS13660 2840949..2841284 + 336 WP_015703743.1 universal stress protein UspB -
GIY00_RS13665 2841350..2842846 - 1497 WP_015369272.1 inorganic phosphate transporter PitA -
GIY00_RS13670 2843077..2844270 + 1194 WP_032709350.1 NAD(P)/FAD-dependent oxidoreductase -
GIY00_RS13675 2844311..2845324 - 1014 WP_015369274.1 magnesium transporter -
GIY00_RS13680 2845721..2845996 + 276 WP_015703741.1 type II toxin-antitoxin system HicA family toxin Toxin
GIY00_RS13685 2845993..2846352 + 360 WP_015703740.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GIY00_RS13690 2846380..2846781 - 402 WP_032709347.1 nickel-responsive transcriptional regulator NikR -
GIY00_RS13695 2846769..2847560 - 792 WP_032709345.1 nickel import ATP-binding protein NikE -
GIY00_RS13700 2847557..2848321 - 765 WP_015703737.1 nickel import ATP-binding protein NikD -
GIY00_RS13705 2848321..2849154 - 834 WP_015369278.1 nickel ABC transporter permease subunit NikC -
GIY00_RS13710 2849151..2850095 - 945 WP_015703735.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10258.89 Da        Isoelectric Point: 10.4888

>T142940 WP_015703741.1 NZ_CP045870:2845721-2845996 [Klebsiella aerogenes]
MEQQVLSLRKKQRNTLEQLFKTPVPQGIKWADIESLIKALGGEIKEGRGSRCKFLLNHSIASFHRPHPSPDTDKGAVESV
RDWLITIGVKP

Download         Length: 276 bp

>T142940 NZ_CP060908:c1877925-1877551 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCCA
CAACTACAGAACGGTGAACAATATCACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13305.02 Da        Isoelectric Point: 4.3472

>AT142940 WP_015703740.1 NZ_CP045870:2845993-2846352 [Klebsiella aerogenes]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQQEGEISLQEYLADCREAGIEPYAQPEKLKT
FTLRYPESFGERLSSAAAEEQVSVNTWILETLNERLKQA

Download         Length: 360 bp

>AT142940 NZ_CP060908:c1878383-1878015 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FL31

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FNK6

References