Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1324175..1324794 Replicon chromosome
Accession NZ_CP045870
Organism Klebsiella aerogenes strain Y1

Toxin (Protein)


Gene name Hha Uniprot ID A0A0H3FXE2
Locus tag GIY00_RS06500 Protein ID WP_015367918.1
Coordinates 1324576..1324794 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0H3FPM3
Locus tag GIY00_RS06495 Protein ID WP_015367917.1
Coordinates 1324175..1324549 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GIY00_RS06485 1319334..1320533 + 1200 WP_020079451.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
GIY00_RS06490 1320556..1323702 + 3147 WP_015704610.1 multidrug efflux RND transporter permease subunit -
GIY00_RS06495 1324175..1324549 + 375 WP_015367917.1 Hha toxicity modulator TomB Antitoxin
GIY00_RS06500 1324576..1324794 + 219 WP_015367918.1 hemolysin expression modulator Hha Toxin
GIY00_RS06505 1324926..1325489 + 564 WP_015704609.1 maltose O-acetyltransferase -
GIY00_RS06510 1325615..1326079 + 465 WP_015367920.1 YlaC family protein -
GIY00_RS06515 1326054..1327508 - 1455 WP_032707558.1 PLP-dependent aminotransferase family protein -
GIY00_RS06520 1327611..1328321 + 711 WP_015704607.1 GNAT family N-acetyltransferase -
GIY00_RS06525 1328318..1328458 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
GIY00_RS06530 1328461..1328721 - 261 WP_015367923.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8569.96 Da        Isoelectric Point: 9.4828

>T142939 WP_015367918.1 NZ_CP045870:1324576-1324794 [Klebsiella aerogenes]
MSGKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T142939 NZ_CP060908:1844040-1844294 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAGCATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14464.21 Da        Isoelectric Point: 4.9045

>AT142939 WP_015367917.1 NZ_CP045870:1324175-1324549 [Klebsiella aerogenes]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNRGWVNDPTSAVNLQLNELIEHIATYALNYKIKYAEDNKLISQLDEYL
DDTFMLFSSYGINTSDLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT142939 NZ_CP060908:1843792-1844043 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FXE2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FPM3

References