Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3377902..3378559 Replicon chromosome
Accession NZ_CP045869
Organism Klebsiella aerogenes strain Y3

Toxin (Protein)


Gene name cptA Uniprot ID A0A0H3FM52
Locus tag GIY01_RS16320 Protein ID WP_015369792.1
Coordinates 3378149..3378559 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag GIY01_RS16315 Protein ID WP_032709107.1
Coordinates 3377902..3378168 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GIY01_RS16290 3373129..3374562 - 1434 WP_032709109.1 6-phospho-beta-glucosidase BglA -
GIY01_RS16295 3374682..3375410 - 729 WP_015369788.1 MurR/RpiR family transcriptional regulator -
GIY01_RS16300 3375461..3375772 + 312 WP_015703422.1 N(4)-acetylcytidine aminohydrolase -
GIY01_RS16305 3375937..3376596 + 660 WP_008806429.1 hemolysin III family protein -
GIY01_RS16310 3376695..3377678 - 984 WP_032709108.1 tRNA-modifying protein YgfZ -
GIY01_RS16315 3377902..3378168 + 267 WP_032709107.1 FAD assembly factor SdhE Antitoxin
GIY01_RS16320 3378149..3378559 + 411 WP_015369792.1 protein YgfX Toxin
GIY01_RS16325 3378567..3379088 - 522 WP_015369793.1 flavodoxin FldB -
GIY01_RS16330 3379189..3380085 + 897 WP_015703420.1 site-specific tyrosine recombinase XerD -
GIY01_RS16335 3380108..3380821 + 714 WP_015369795.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GIY01_RS16340 3380827..3382560 + 1734 WP_015369796.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15887.69 Da        Isoelectric Point: 10.0200

>T142929 WP_015369792.1 NZ_CP045869:3378149-3378559 [Klebsiella aerogenes]
VVLWQSDLRISWRSQWFSLLLHGVVAAIVLLMPWPLSYTPIWLLLLSLVVFDCVRSQRRIHACQGEIKLLIDSRLRWQKT
EWDIVGTPWVISSGMLLRLKHAETGRSQHLWVAADSMDAGEWRDLRRLVLQKPAHD

Download         Length: 411 bp

>T142929 NZ_CP060904:41238-41390 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10609.12 Da        Isoelectric Point: 5.6963

>AT142929 WP_032709107.1 NZ_CP045869:3377902-3378168 [Klebsiella aerogenes]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGKPADTQLQRMINLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT142929 NZ_CP060904:c41186-41126 [Escherichia coli]
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FM52

Antitoxin

Source ID Structure

References