Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2810482..2811113 Replicon chromosome
Accession NZ_CP045869
Organism Klebsiella aerogenes strain Y3

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H3FL31
Locus tag GIY01_RS13470 Protein ID WP_015703741.1
Coordinates 2810482..2810757 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0H3FNK6
Locus tag GIY01_RS13475 Protein ID WP_015703740.1
Coordinates 2810754..2811113 (+) Length 120 a.a.

Genomic Context

GIY01_RS13450GIY01_RS13460GIY01_RS13470GIY01_RS13475GIY01_RS13455GIY01_RS13465GIY01_RS13480GIY01_RS13485GIY01_RS13490GIY01_RS13495GIY01_RS13500
Location: 2805710..2806045 (336 bp)
Type: Others
Protein ID: WP_015703743.1
Location: 2807838..2809031 (1194 bp)
Type: Others
Protein ID: WP_032709350.1
Location: 2810482..2810757 (276 bp)
Type: Toxin
Protein ID: WP_015703741.1
Location: 2810754..2811113 (360 bp)
Type: Antitoxin
Protein ID: WP_015703740.1
Location: 2806111..2807607 (1497 bp)
Type: Others
Protein ID: WP_015369272.1
Location: 2809072..2810085 (1014 bp)
Type: Others
Protein ID: WP_015369274.1
Location: 2811141..2811542 (402 bp)
Type: Others
Protein ID: WP_032709347.1
Location: 2811530..2812321 (792 bp)
Type: Others
Protein ID: WP_032709345.1
Location: 2812318..2813082 (765 bp)
Type: Others
Protein ID: WP_015703737.1
Location: 2813082..2813915 (834 bp)
Type: Others
Protein ID: WP_015369278.1
Location: 2813912..2814856 (945 bp)
Type: Others
Protein ID: WP_015703735.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GIY01_RS134502805710..2806045+336WP_015703743.1universal stress protein UspB-
GIY01_RS134552806111..2807607-1497WP_015369272.1inorganic phosphate transporter PitA-
GIY01_RS134602807838..2809031+1194WP_032709350.1NAD(P)/FAD-dependent oxidoreductase-
GIY01_RS134652809072..2810085-1014WP_015369274.1magnesium transporter-
GIY01_RS134702810482..2810757+276WP_015703741.1type II toxin-antitoxin system HicA family toxinToxin
GIY01_RS134752810754..2811113+360WP_015703740.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
GIY01_RS134802811141..2811542-402WP_032709347.1nickel-responsive transcriptional regulator NikR-
GIY01_RS134852811530..2812321-792WP_032709345.1nickel import ATP-binding protein NikE-
GIY01_RS134902812318..2813082-765WP_015703737.1nickel import ATP-binding protein NikD-
GIY01_RS134952813082..2813915-834WP_015369278.1nickel ABC transporter permease subunit NikC-
GIY01_RS135002813912..2814856-945WP_015703735.1nickel ABC transporter permease subunit NikB-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10258.89 Da        Isoelectric Point: 10.4888

>T142927 WP_015703741.1 NZ_CP045869:2810482-2810757 [Klebsiella aerogenes]
MEQQVLSLRKKQRNTLEQLFKTPVPQGIKWADIESLIKALGGEIKEGRGSRCKFLLNHSIASFHRPHPSPDTDKGAVESV
RDWLITIGVKP

Download         Length: 276 bp

>T142927 NZ_CP060903:c65400-65095 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTCCAGAGTGACATTATTGACAC
GCCTGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGTTGTCAGATAAGGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAGGAAGTG
GCTGATCTCAGCCACCGAGAAAATGACATCAAAAATGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13305.02 Da        Isoelectric Point: 4.3472

>AT142927 WP_015703740.1 NZ_CP045869:2810754-2811113 [Klebsiella aerogenes]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQQEGEISLQEYLADCREAGIEPYAQPEKLKT
FTLRYPESFGERLSSAAAEEQVSVNTWILETLNERLKQA

Download         Length: 360 bp

>AT142927 NZ_CP060903:c65620-65402 [Escherichia coli]
ATGAAGCAGCGCATTACAGTCACCGTCGACAGTGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGGCT
GGTAAGCACCACCCTGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGCAGGCAGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0H3FL31

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0H3FNK6

References