Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1284537..1285156 Replicon chromosome
Accession NZ_CP045869
Organism Klebsiella aerogenes strain Y3

Toxin (Protein)


Gene name Hha Uniprot ID A0A0H3FXE2
Locus tag GIY01_RS06235 Protein ID WP_015367918.1
Coordinates 1284938..1285156 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0H3FPM3
Locus tag GIY01_RS06230 Protein ID WP_015367917.1
Coordinates 1284537..1284911 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GIY01_RS06220 1279696..1280895 + 1200 WP_020079451.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
GIY01_RS06225 1280918..1284064 + 3147 WP_015704610.1 multidrug efflux RND transporter permease subunit -
GIY01_RS06230 1284537..1284911 + 375 WP_015367917.1 Hha toxicity modulator TomB Antitoxin
GIY01_RS06235 1284938..1285156 + 219 WP_015367918.1 hemolysin expression modulator Hha Toxin
GIY01_RS06240 1285288..1285851 + 564 WP_015704609.1 maltose O-acetyltransferase -
GIY01_RS06245 1285977..1286441 + 465 WP_015367920.1 YlaC family protein -
GIY01_RS06250 1286416..1287870 - 1455 WP_032707558.1 PLP-dependent aminotransferase family protein -
GIY01_RS06255 1287973..1288683 + 711 WP_015704607.1 GNAT family N-acetyltransferase -
GIY01_RS06260 1288680..1288820 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
GIY01_RS06265 1288823..1289083 - 261 WP_015367923.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8569.96 Da        Isoelectric Point: 9.4828

>T142926 WP_015367918.1 NZ_CP045869:1284938-1285156 [Klebsiella aerogenes]
MSGKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T142926 NZ_CP060903:c43598-43449 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14464.21 Da        Isoelectric Point: 4.9045

>AT142926 WP_015367917.1 NZ_CP045869:1284537-1284911 [Klebsiella aerogenes]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNRGWVNDPTSAVNLQLNELIEHIATYALNYKIKYAEDNKLISQLDEYL
DDTFMLFSSYGINTSDLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT142926 NZ_CP060903:43642-43703 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FXE2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FPM3

References