Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 14581..15320 Replicon chromosome
Accession NZ_CP045869
Organism Klebsiella aerogenes strain Y3

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag GIY01_RS00095 Protein ID WP_032705770.1
Coordinates 14835..15320 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A0H3FSM9
Locus tag GIY01_RS00090 Protein ID WP_015705366.1
Coordinates 14581..14847 (+) Length 89 a.a.

Genomic Context

GIY01_RS00065GIY01_RS00070GIY01_RS00075GIY01_RS00080GIY01_RS00090GIY01_RS00095GIY01_RS00100GIY01_RS00105GIY01_RS00115GIY01_RS00085GIY01_RS00110
Location: 9916..10503 (588 bp)
Type: Others
Protein ID: WP_015705371.1
Location: 10500..11819 (1320 bp)
Type: Others
Protein ID: WP_015705370.1
Location: 11819..12436 (618 bp)
Type: Others
Protein ID: WP_015705369.1
Location: 12532..13029 (498 bp)
Type: Others
Protein ID: WP_032708018.1
Location: 14581..14847 (267 bp)
Type: Antitoxin
Protein ID: WP_015705366.1
Location: 14835..15320 (486 bp)
Type: Toxin
Protein ID: WP_032705770.1
Location: 15392..17008 (1617 bp)
Type: Others
Protein ID: WP_032708017.1
Location: 17127..18227 (1101 bp)
Type: Others
Protein ID: WP_032708016.1
Location: 18703..19773 (1071 bp)
Type: Others
Protein ID: WP_032708015.1
Location: 13073..14308 (1236 bp)
Type: Others
Protein ID: WP_020078885.1
Location: 18284..18442 (159 bp)
Type: Others
Protein ID: WP_002903230.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GIY01_RS000659916..10503+588WP_015705371.1hypothetical protein-
GIY01_RS0007010500..11819+1320WP_015705370.1two-component sensor histidine kinase-
GIY01_RS0007511819..12436+618WP_015705369.1response regulator transcription factor-
GIY01_RS0008012532..13029+498WP_032708018.1heme-binding protein-
GIY01_RS0008513073..14308-1236WP_020078885.1MFS transporter-
GIY01_RS0009014581..14847+267WP_015705366.1DUF1778 domain-containing proteinAntitoxin
GIY01_RS0009514835..15320+486WP_032705770.1GNAT family N-acetyltransferaseToxin
GIY01_RS0010015392..17008+1617WP_032708017.1FAD-NAD(P)-binding protein-
GIY01_RS0010517127..18227+1101WP_032708016.1NADH:flavin oxidoreductase/NADH oxidase-
GIY01_RS0011018284..18442-159WP_002903230.1YqaE/Pmp3 family membrane protein-
GIY01_RS0011518703..19773+1071WP_032708015.1mannonate dehydratase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17573.23 Da        Isoelectric Point: 8.8793

>T142925 WP_032705770.1 NZ_CP045869:14835-15320 [Klebsiella aerogenes]
MGKISAPAPLSSHHQIAEFCCGETVLDQWLKQRGLKNQAQGAARTFVVCKEESHQVVGFYSLATGSVNHSEATGGLRRNM
PDPIPVIILARLAIDCAFHGQGLGADLLHDALLRSYRVAENVGVRALMVHALTDSAKRFYLHHGFKASTTQERTLFLALP
K

Download         Length: 486 bp

>T142925 NZ_CP060902:c4365710-4365537 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10085.56 Da        Isoelectric Point: 4.6558

>AT142925 WP_015705366.1 NZ_CP045869:14581-14847 [Klebsiella aerogenes]
MKSDIQLNIRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNLSDEQYAEFIDMLDAPVEANPALDKLL
ARKPQWEK

Download         Length: 267 bp

>AT142925 NZ_CP060902:c4366034-4365738 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTAATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0H3FSM9

References