Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 2864622..2865208 Replicon chromosome
Accession NZ_CP045868
Organism Klebsiella aerogenes strain Y6

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag GIY02_RS13785 Protein ID WP_032709318.1
Coordinates 2864840..2865208 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag GIY02_RS13780 Protein ID WP_004174006.1
Coordinates 2864622..2864843 (+) Length 74 a.a.

Genomic Context

GIY02_RS13760GIY02_RS13765GIY02_RS13770GIY02_RS13775GIY02_RS13780GIY02_RS13785GIY02_RS13790GIY02_RS13795GIY02_RS13800GIY02_RS13805
Location: 2860763..2861689 (927 bp)
Type: Others
Protein ID: WP_015369323.1
Location: 2861686..2862963 (1278 bp)
Type: Others
Protein ID: WP_015369324.1
Location: 2862960..2863727 (768 bp)
Type: Others
Protein ID: WP_032709319.1
Location: 2863745..2864458 (714 bp)
Type: Others
Protein ID: WP_086538103.1
Location: 2864622..2864843 (222 bp)
Type: Antitoxin
Protein ID: WP_004174006.1
Location: 2864840..2865208 (369 bp)
Type: Toxin
Protein ID: WP_032709318.1
Location: 2865500..2866816 (1317 bp)
Type: Others
Protein ID: WP_015703703.1
Location: 2866923..2867810 (888 bp)
Type: Others
Protein ID: WP_015369328.1
Location: 2867807..2868652 (846 bp)
Type: Others
Protein ID: WP_015369329.1
Location: 2868654..2869724 (1071 bp)
Type: Others
Protein ID: WP_032709316.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GIY02_RS137602860763..2861689+927WP_015369323.1high-affinity branched-chain amino acid ABC transporter permease LivH-
GIY02_RS137652861686..2862963+1278WP_015369324.1branched chain amino acid ABC transporter permease LivM-
GIY02_RS137702862960..2863727+768WP_032709319.1high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG-
GIY02_RS137752863745..2864458+714WP_086538103.1high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF-
GIY02_RS137802864622..2864843+222WP_004174006.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
GIY02_RS137852864840..2865208+369WP_032709318.1type II toxin-antitoxin system death-on-curing family toxinToxin
GIY02_RS137902865500..2866816+1317WP_015703703.1sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB-
GIY02_RS137952866923..2867810+888WP_015369328.1sn-glycerol-3-phosphate ABC transporter permease UgpA-
GIY02_RS138002867807..2868652+846WP_015369329.1sn-glycerol-3-phosphate ABC transporter permease UgpE-
GIY02_RS138052868654..2869724+1071WP_032709316.1sn-glycerol-3-phosphate import ATP-binding protein UgpC-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--2860763..28704619698


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.97 Da        Isoelectric Point: 9.7753

>T142915 WP_032709318.1 NZ_CP045868:2864840-2865208 [Klebsiella aerogenes]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGKLTLEQIVARLRG

Download         Length: 369 bp

>T142915 NZ_CP060902:1119246-1119557 [Escherichia coli]
ATGCACATCATTTCTAAAGCGCCATTTGAAGAGTCTGCGCGTAAATATCCTAACGACGCTCTGGCTCTTCAGGCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAGATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT142915 WP_004174006.1 NZ_CP045868:2864622-2864843 [Klebsiella aerogenes]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT142915 NZ_CP060902:1119554-1119973 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAGTATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCGGCAATGCCGGTT
GGCGTGGCGTTACTTCGCACGTTGATTGATCAACATAATCTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGTCAGATTTTGTCTGGACAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A5E5YJY7

References