Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2815148..2815779 Replicon chromosome
Accession NZ_CP045868
Organism Klebsiella aerogenes strain Y6

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H3FL31
Locus tag GIY02_RS13505 Protein ID WP_015703741.1
Coordinates 2815148..2815423 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0H3FNK6
Locus tag GIY02_RS13510 Protein ID WP_015703740.1
Coordinates 2815420..2815779 (+) Length 120 a.a.

Genomic Context

GIY02_RS13485GIY02_RS13495GIY02_RS13505GIY02_RS13510GIY02_RS13490GIY02_RS13500GIY02_RS13515GIY02_RS13520GIY02_RS13525GIY02_RS13530GIY02_RS13535
Location: 2810376..2810711 (336 bp)
Type: Others
Protein ID: WP_015703743.1
Location: 2812504..2813697 (1194 bp)
Type: Others
Protein ID: WP_032709350.1
Location: 2815148..2815423 (276 bp)
Type: Toxin
Protein ID: WP_015703741.1
Location: 2815420..2815779 (360 bp)
Type: Antitoxin
Protein ID: WP_015703740.1
Location: 2810777..2812273 (1497 bp)
Type: Others
Protein ID: WP_015369272.1
Location: 2813738..2814751 (1014 bp)
Type: Others
Protein ID: WP_015369274.1
Location: 2815807..2816208 (402 bp)
Type: Others
Protein ID: WP_032709347.1
Location: 2816196..2816987 (792 bp)
Type: Others
Protein ID: WP_032709345.1
Location: 2816984..2817748 (765 bp)
Type: Others
Protein ID: WP_015703737.1
Location: 2817748..2818581 (834 bp)
Type: Others
Protein ID: WP_015369278.1
Location: 2818578..2819522 (945 bp)
Type: Others
Protein ID: WP_015703735.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GIY02_RS134852810376..2810711+336WP_015703743.1universal stress protein UspB-
GIY02_RS134902810777..2812273-1497WP_015369272.1inorganic phosphate transporter PitA-
GIY02_RS134952812504..2813697+1194WP_032709350.1NAD(P)/FAD-dependent oxidoreductase-
GIY02_RS135002813738..2814751-1014WP_015369274.1magnesium transporter-
GIY02_RS135052815148..2815423+276WP_015703741.1type II toxin-antitoxin system HicA family toxinToxin
GIY02_RS135102815420..2815779+360WP_015703740.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
GIY02_RS135152815807..2816208-402WP_032709347.1nickel-responsive transcriptional regulator NikR-
GIY02_RS135202816196..2816987-792WP_032709345.1nickel import ATP-binding protein NikE-
GIY02_RS135252816984..2817748-765WP_015703737.1nickel import ATP-binding protein NikD-
GIY02_RS135302817748..2818581-834WP_015369278.1nickel ABC transporter permease subunit NikC-
GIY02_RS135352818578..2819522-945WP_015703735.1nickel ABC transporter permease subunit NikB-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10258.89 Da        Isoelectric Point: 10.4888

>T142914 WP_015703741.1 NZ_CP045868:2815148-2815423 [Klebsiella aerogenes]
MEQQVLSLRKKQRNTLEQLFKTPVPQGIKWADIESLIKALGGEIKEGRGSRCKFLLNHSIASFHRPHPSPDTDKGAVESV
RDWLITIGVKP

Download         Length: 276 bp

>T142914 NZ_CP060902:1052996-1053331 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13305.02 Da        Isoelectric Point: 4.3472

>AT142914 WP_015703740.1 NZ_CP045868:2815420-2815779 [Klebsiella aerogenes]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQQEGEISLQEYLADCREAGIEPYAQPEKLKT
FTLRYPESFGERLSSAAAEEQVSVNTWILETLNERLKQA

Download         Length: 360 bp

>AT142914 NZ_CP060902:1052748-1052996 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0H3FL31

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0H3FNK6

References