Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 19188..19927 Replicon chromosome
Accession NZ_CP045868
Organism Klebsiella aerogenes strain Y6

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag GIY02_RS00130 Protein ID WP_032705770.1
Coordinates 19442..19927 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A0H3FSM9
Locus tag GIY02_RS00125 Protein ID WP_015705366.1
Coordinates 19188..19454 (+) Length 89 a.a.

Genomic Context

GIY02_RS00100GIY02_RS00105GIY02_RS00110GIY02_RS00115GIY02_RS00125GIY02_RS00130GIY02_RS00135GIY02_RS00140GIY02_RS00150GIY02_RS00120GIY02_RS00145
Location: 14523..15110 (588 bp)
Type: Others
Protein ID: WP_015705371.1
Location: 15107..16426 (1320 bp)
Type: Others
Protein ID: WP_015705370.1
Location: 16426..17043 (618 bp)
Type: Others
Protein ID: WP_015705369.1
Location: 17139..17636 (498 bp)
Type: Others
Protein ID: WP_032708018.1
Location: 19188..19454 (267 bp)
Type: Antitoxin
Protein ID: WP_015705366.1
Location: 19442..19927 (486 bp)
Type: Toxin
Protein ID: WP_032705770.1
Location: 19999..21615 (1617 bp)
Type: Others
Protein ID: WP_032708017.1
Location: 21734..22834 (1101 bp)
Type: Others
Protein ID: WP_032708016.1
Location: 23310..24380 (1071 bp)
Type: Others
Protein ID: WP_032708015.1
Location: 17680..18915 (1236 bp)
Type: Others
Protein ID: WP_020078885.1
Location: 22891..23049 (159 bp)
Type: Others
Protein ID: WP_002903230.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GIY02_RS0010014523..15110+588WP_015705371.1hypothetical protein-
GIY02_RS0010515107..16426+1320WP_015705370.1two-component sensor histidine kinase-
GIY02_RS0011016426..17043+618WP_015705369.1response regulator transcription factor-
GIY02_RS0011517139..17636+498WP_032708018.1heme-binding protein-
GIY02_RS0012017680..18915-1236WP_020078885.1MFS transporter-
GIY02_RS0012519188..19454+267WP_015705366.1DUF1778 domain-containing proteinAntitoxin
GIY02_RS0013019442..19927+486WP_032705770.1GNAT family N-acetyltransferaseToxin
GIY02_RS0013519999..21615+1617WP_032708017.1FAD-NAD(P)-binding protein-
GIY02_RS0014021734..22834+1101WP_032708016.1NADH:flavin oxidoreductase/NADH oxidase-
GIY02_RS0014522891..23049-159WP_002903230.1YqaE/Pmp3 family membrane protein-
GIY02_RS0015023310..24380+1071WP_032708015.1mannonate dehydratase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17573.23 Da        Isoelectric Point: 8.8793

>T142912 WP_032705770.1 NZ_CP045868:19442-19927 [Klebsiella aerogenes]
MGKISAPAPLSSHHQIAEFCCGETVLDQWLKQRGLKNQAQGAARTFVVCKEESHQVVGFYSLATGSVNHSEATGGLRRNM
PDPIPVIILARLAIDCAFHGQGLGADLLHDALLRSYRVAENVGVRALMVHALTDSAKRFYLHHGFKASTTQERTLFLALP
K

Download         Length: 486 bp

>T142912 NZ_CP060902:777288-777584 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATACCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10085.56 Da        Isoelectric Point: 4.6558

>AT142912 WP_015705366.1 NZ_CP045868:19188-19454 [Klebsiella aerogenes]
MKSDIQLNIRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNLSDEQYAEFIDMLDAPVEANPALDKLL
ARKPQWEK

Download         Length: 267 bp

>AT142912 NZ_CP060902:777586-777981 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0H3FSM9

References