Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1132650..1133426 Replicon chromosome
Accession NZ_CP045866
Organism Staphylococcus aureus strain CFSAN007894

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag AB466_RS05435 Protein ID WP_000031108.1
Coordinates 1132650..1132802 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag AB466_RS05440 Protein ID WP_001251224.1
Coordinates 1132827..1133426 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB466_RS05420 1128852..1129673 + 822 WP_000669376.1 RluA family pseudouridine synthase -
AB466_RS05425 1130126..1131511 - 1386 WP_000116228.1 class II fumarate hydratase -
AB466_RS05430 1131707..1132102 - 396 WP_000901023.1 hypothetical protein -
AB466_RS05435 1132650..1132802 - 153 WP_000031108.1 hypothetical protein Toxin
AB466_RS05440 1132827..1133426 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
AB466_RS05445 1133585..1134055 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
AB466_RS05450 1134060..1135187 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
AB466_RS05455 1135338..1136060 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
AB466_RS05460 1136053..1137510 - 1458 WP_000649908.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T142899 WP_000031108.1 NZ_CP045866:c1132802-1132650 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T142899 NZ_CP060899:2607919-2608026 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT142899 WP_001251224.1 NZ_CP045866:c1133426-1132827 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT142899 NZ_CP060899:c2607869-2607806 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References