Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 101519..101996 Replicon chromosome
Accession NZ_CP045866
Organism Staphylococcus aureus strain CFSAN007894

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag AB466_RS00515 Protein ID WP_000052076.1
Coordinates 101519..101707 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag AB466_RS00520 Protein ID WP_001059690.1
Coordinates 101736..101996 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB466_RS00485 97513..98034 + 522 WP_049311898.1 hypothetical protein -
AB466_RS00490 98375..99061 + 687 WP_000141557.1 thermonuclease family protein -
AB466_RS00495 99418..99618 + 201 WP_001059082.1 cold-shock protein -
AB466_RS00500 100110..100328 - 219 WP_000005886.1 hypothetical protein -
AB466_RS00505 100390..100674 - 285 WP_001004399.1 hypothetical protein -
AB466_RS00510 100762..101331 - 570 WP_001106654.1 hypothetical protein -
AB466_RS00515 101519..101707 - 189 WP_000052076.1 hypothetical protein Toxin
AB466_RS00520 101736..101996 - 261 WP_001059690.1 hypothetical protein Antitoxin
AB466_RS00525 102337..102540 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
AB466_RS00530 102537..102773 - 237 WP_000349581.1 hypothetical protein -
AB466_RS00535 102998..103579 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
AB466_RS00540 103652..104269 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
AB466_RS00545 104424..104918 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
AB466_RS00550 105317..105739 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
AB466_RS00555 105887..106603 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vWbp 68381..104918 36537


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(88-134)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T142896 WP_000052076.1 NZ_CP045866:c101707-101519 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T142896 NZ_CP060899:c2379040-2378864 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT142896 WP_001059690.1 NZ_CP045866:c101996-101736 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT142896 NZ_CP060899:c2378818-2378402 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References