Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1439306..1439865 Replicon chromosome
Accession NZ_CP045859
Organism Vibrio owensii strain SH14

Toxin (Protein)


Gene name relE Uniprot ID A0A347UR22
Locus tag APZ19_RS06725 Protein ID WP_005398411.1
Coordinates 1439306..1439584 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3G2PT85
Locus tag APZ19_RS06730 Protein ID WP_054824926.1
Coordinates 1439581..1439865 (-) Length 95 a.a.

Genomic Context

APZ19_RS06705APZ19_RS06710APZ19_RS06715APZ19_RS06735APZ19_RS06740APZ19_RS06745APZ19_RS06750APZ19_RS06755APZ19_RS06760APZ19_RS06765APZ19_RS06770APZ19_RS06775APZ19_RS06780APZ19_RS06785APZ19_RS06790APZ19_RS06720APZ19_RS06725APZ19_RS06730
Location: 1435838..1436422 (585 bp)
Type: Others
Protein ID: WP_038896808.1
Location: 1436423..1437010 (588 bp)
Type: Others
Protein ID: WP_054824176.1
Location: 1437024..1437497 (474 bp)
Type: Others
Protein ID: WP_054824177.1
Location: 1439942..1440055 (114 bp)
Type: Others
Protein ID: WP_104047644.1
Location: 1440488..1440580 (93 bp)
Type: Others
Protein ID: WP_005445221.1
Location: 1440612..1441040 (429 bp)
Type: Others
Protein ID: WP_054824934.1
Location: 1441055..1441147 (93 bp)
Type: Others
Protein ID: WP_194842408.1
Location: 1441251..1441517 (267 bp)
Type: Others
Protein ID: WP_041061928.1
Location: 1441521..1441643 (123 bp)
Type: Others
Protein ID: WP_080772516.1
Location: 1441684..1442193 (510 bp)
Type: Others
Protein ID: WP_047707023.1
Location: 1442224..1442313 (90 bp)
Type: Others
Protein ID: WP_072609598.1
Location: 1442351..1443604 (1254 bp)
Type: Others
Protein ID: WP_054824855.1
Location: 1443619..1443711 (93 bp)
Type: Others
Protein ID: WP_194842420.1
Location: 1443692..1444480 (789 bp)
Type: Others
Protein ID: WP_122044962.1
Location: 1444495..1444587 (93 bp)
Type: Others
Protein ID: WP_194842409.1
Location: 1437556..1438518 (963 bp)
Type: Others
Protein ID: WP_054824178.1
Location: 1439306..1439584 (279 bp)
Type: Toxin
Protein ID: WP_005398411.1
Location: 1439581..1439865 (285 bp)
Type: Antitoxin
Protein ID: WP_054824926.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
APZ19_RS067051435838..1436422+585WP_038896808.1ribosomal protein S5-alanine N-acetyltransferase-
APZ19_RS067101436423..1437010+588WP_054824176.1HD domain-containing protein-
APZ19_RS067151437024..1437497+474WP_054824177.1DUF2947 domain-containing protein-
APZ19_RS067201437556..1438518-963WP_054824178.1integron integrase-
APZ19_RS067251439306..1439584-279WP_005398411.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
APZ19_RS067301439581..1439865-285WP_054824926.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
APZ19_RS067351439942..1440055+114WP_104047644.1DUF3265 domain-containing protein-
APZ19_RS067401440488..1440580+93WP_005445221.1DUF3265 domain-containing protein-
APZ19_RS067451440612..1441040+429WP_054824934.1ester cyclase-
APZ19_RS067501441055..1441147+93WP_194842408.1DUF3265 domain-containing protein-
APZ19_RS067551441251..1441517+267WP_041061928.1hypothetical protein-
APZ19_RS067601441521..1441643+123WP_080772516.1DUF3265 domain-containing protein-
APZ19_RS067651441684..1442193+510WP_047707023.1SMI1/KNR4 family protein-
APZ19_RS067701442224..1442313+90WP_072609598.1DUF3265 domain-containing protein-
APZ19_RS067751442351..1443604+1254WP_054824855.1hypothetical protein-
APZ19_RS067801443619..1443711+93WP_194842420.1DUF3265 domain-containing protein-
APZ19_RS067851443692..1444480+789WP_122044962.1hypothetical protein-
APZ19_RS067901444495..1444587+93WP_194842409.1DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--1439306..150995470648
-insideIntegron--1437556..150261165055


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10891.57 Da        Isoelectric Point: 4.3430

>T142860 WP_005398411.1 NZ_CP045859:c1439584-1439306 [Vibrio owensii]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD

Download         Length: 279 bp

>T142860 NZ_CP060886:c65390-65085 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTCCAGAGTGACATTATTGACAC
GCCTGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGTTGTCAGATAAGGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAGGAAGTG
GCTGATCTCAGCCACCGAGAAAATGACATCAAAAATGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11000.29 Da        Isoelectric Point: 8.0517

>AT142860 WP_054824926.1 NZ_CP045859:c1439865-1439581 [Vibrio owensii]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEESKARIRNRGKQ

Download         Length: 285 bp

>AT142860 NZ_CP060886:c65610-65392 [Escherichia coli]
ATGAAGCAGCGCATTACAGTCACCGTCGACAGTGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGGCT
GGTAAGCACCACCCTGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGCAGGCAGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A347UR22

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A3G2PT85

References