Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1439306..1439865 Replicon chromosome
Accession NZ_CP045859
Organism Vibrio owensii strain SH14

Toxin (Protein)


Gene name relE Uniprot ID A0A347UR22
Locus tag APZ19_RS06725 Protein ID WP_005398411.1
Coordinates 1439306..1439584 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3G2PT85
Locus tag APZ19_RS06730 Protein ID WP_054824926.1
Coordinates 1439581..1439865 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APZ19_RS06705 1435838..1436422 + 585 WP_038896808.1 ribosomal protein S5-alanine N-acetyltransferase -
APZ19_RS06710 1436423..1437010 + 588 WP_054824176.1 HD domain-containing protein -
APZ19_RS06715 1437024..1437497 + 474 WP_054824177.1 DUF2947 domain-containing protein -
APZ19_RS06720 1437556..1438518 - 963 WP_054824178.1 integron integrase -
APZ19_RS06725 1439306..1439584 - 279 WP_005398411.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
APZ19_RS06730 1439581..1439865 - 285 WP_054824926.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
APZ19_RS06735 1439942..1440055 + 114 WP_104047644.1 DUF3265 domain-containing protein -
APZ19_RS06740 1440488..1440580 + 93 WP_005445221.1 DUF3265 domain-containing protein -
APZ19_RS06745 1440612..1441040 + 429 WP_054824934.1 ester cyclase -
APZ19_RS06750 1441055..1441147 + 93 WP_194842408.1 DUF3265 domain-containing protein -
APZ19_RS06755 1441251..1441517 + 267 WP_041061928.1 hypothetical protein -
APZ19_RS06760 1441521..1441643 + 123 WP_080772516.1 DUF3265 domain-containing protein -
APZ19_RS06765 1441684..1442193 + 510 WP_047707023.1 SMI1/KNR4 family protein -
APZ19_RS06770 1442224..1442313 + 90 WP_072609598.1 DUF3265 domain-containing protein -
APZ19_RS06775 1442351..1443604 + 1254 WP_054824855.1 hypothetical protein -
APZ19_RS06780 1443619..1443711 + 93 WP_194842420.1 DUF3265 domain-containing protein -
APZ19_RS06785 1443692..1444480 + 789 WP_122044962.1 hypothetical protein -
APZ19_RS06790 1444495..1444587 + 93 WP_194842409.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1439306..1509954 70648
- inside Integron - - 1437556..1502611 65055


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10891.57 Da        Isoelectric Point: 4.3430

>T142860 WP_005398411.1 NZ_CP045859:c1439584-1439306 [Vibrio owensii]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD

Download         Length: 279 bp

>T142860 NZ_CP060886:c65390-65085 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTCCAGAGTGACATTATTGACAC
GCCTGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGTTGTCAGATAAGGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAGGAAGTG
GCTGATCTCAGCCACCGAGAAAATGACATCAAAAATGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11000.29 Da        Isoelectric Point: 8.0517

>AT142860 WP_054824926.1 NZ_CP045859:c1439865-1439581 [Vibrio owensii]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEESKARIRNRGKQ

Download         Length: 285 bp

>AT142860 NZ_CP060886:c65610-65392 [Escherichia coli]
ATGAAGCAGCGCATTACAGTCACCGTCGACAGTGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGGCT
GGTAAGCACCACCCTGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGCAGGCAGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR22

Antitoxin

Source ID Structure
AlphaFold DB A0A3G2PT85

References