Detailed information of TA system TA142859

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-StbC
• Location: 4093954..4094621
• Replicon: chromosome
• Accession: NZ_CP045858
• Organism: Pseudomonas balearica strain EC28

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: GII23_RS19325
• Protein ID: WP_165563907.1
• Coordinates: 4094196..4094621 (+)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: GII23_RS19320
• Protein ID: WP_165563906.1
• Coordinates: 4093954..4094199 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GII23_RS19300	4089196..4089591	+	396	WP_043218856.1	MerR family DNA-binding transcriptional regulator	-
GII23_RS19305	4090488..4091414	-	927	WP_165563904.1	hypothetical protein	-
GII23_RS19310	4091480..4091806	-	327	WP_165563905.1	hypothetical protein	-
GII23_RS19315	4092440..4093822	-	1383	WP_034018616.1	IS1380 family transposase	-
GII23_RS19320	4093954..4094199	+	246	WP_165563906.1	plasmid stabilization protein	Antitoxin
GII23_RS19325	4094196..4094621	+	426	WP_165563907.1	type II toxin-antitoxin system VapC family toxin	Toxin
GII23_RS19335	4094891..4095775	-	885	WP_043218850.1	DMT family transporter	-
GII23_RS19340	4095799..4096443	-	645	WP_041107521.1	carbonate dehydratase	-
GII23_RS19345	4096529..4097917	-	1389	WP_043218848.1	alpha,alpha-trehalose-phosphate synthase (UDP-forming)	-
GII23_RS19350	4097914..4098702	-	789	WP_165563908.1	trehalose-phosphatase	-
GII23_RS19355	4098852..4099414	+	563	Protein_3797	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 15137.36 Da
• Isoelectric Point: 4.4731

>T142859 WP_165563907.1 NZ_CP045858:4094196-4094621 [Pseudomonas balearica]
MILLDTNVLSELMRAKPAPQVLEWVDAQPASELAISAITVAEILYGLARMPDGKRKQGLLDIASTMFDEDFAGNILPFDA
DAAVHYAEIAAATEAKGRIVDMADAQIAAIGRLHDAVIATRNTRHFEPLGVALVDPWSGRG

Nucleotide

• Length: 426 bp

>T142859 NZ_CP060886:c43588-43439 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8988.27 Da
• Isoelectric Point: 10.8838

>AT142859 WP_165563906.1 NZ_CP045858:4093954-4094199 [Pseudomonas balearica]
MASITIRNLDDDLKAKLRVLAASHGRSMEEEARIIIRQALSRQEKRGGLGTRIHSRFASVGGVDLTLPERKDKARAASFD
E

Nucleotide

• Length: 246 bp

>AT142859 NZ_CP060886:43632-43693 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT