Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 1169895..1170658 Replicon chromosome
Accession NZ_CP045857
Organism Shewanella chilikensis strain DC57

Toxin (Protein)


Gene name ataT Uniprot ID A0A6G7LPD4
Locus tag GII14_RS05470 Protein ID WP_065274325.1
Coordinates 1169895..1170401 (-) Length 169 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A501XZ00
Locus tag GII14_RS05475 Protein ID WP_032481064.1
Coordinates 1170392..1170658 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GII14_RS05440 1165748..1166029 + 282 WP_145573979.1 type IV conjugative transfer system protein TraL -
GII14_RS05445 1166026..1166652 + 627 WP_025441422.1 pilus assembly protein -
GII14_RS05450 1166636..1167532 + 897 WP_165565980.1 type-F conjugative transfer system secretin TraK -
GII14_RS05455 1167535..1168824 + 1290 WP_165564611.1 TraB/VirB10 family protein -
GII14_RS05460 1168899..1169471 + 573 WP_165564612.1 type IV conjugative transfer system lipoprotein TraV -
GII14_RS05465 1169468..1169854 + 387 WP_165564613.1 hypothetical protein -
GII14_RS05470 1169895..1170401 - 507 WP_065274325.1 GNAT family N-acetyltransferase Toxin
GII14_RS05475 1170392..1170658 - 267 WP_032481064.1 DUF1778 domain-containing protein Antitoxin
GII14_RS05480 1171033..1171980 + 948 WP_021024261.1 IS30 family transposase -
GII14_RS05485 1172017..1172463 - 447 Protein_1045 hypothetical protein -
GII14_RS05490 1172891..1173829 - 939 WP_029627976.1 Abi family protein -
GII14_RS05495 1174171..1174866 + 696 WP_165564614.1 DsbC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1141352..1176696 35344
- flank IS/Tn - - 1171033..1171980 947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-146)

Antitoxin

Vibrio phage ICP1, Orf50

(8-83)


Sequences

Toxin        


Download         Length: 169 a.a.        Molecular weight: 18247.98 Da        Isoelectric Point: 7.2132

>T142854 WP_065274325.1 NZ_CP045857:c1170401-1169895 [Shewanella chilikensis]
MGISAPTLLADEHQINAFQCGIEELDTWLRKQALKSQKRGTARVYVVNDTDAHQVVGYYAIAMGSVSREQAFSSLRRNSP
DPIPMVILARLGVDNAYQGQGIAAGLLKDCIIRSVQAMNAVGGAGILVHAIDGSAQTFYKKFGFKESTFDPLVLMARICD
IEKSLSID

Download         Length: 507 bp

>T142854 NZ_CP060885:2437851-2439173 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CAGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTAACGTTATTACCCGAAAA
TGAAACCATAACGCGCCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGGCTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTTAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAAGATATGTGTCAGACATTCGGTTTACCTTCATCTGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCGTTTTTGATGGGGTCCAGCGAGGCGCTTCGCGATCGTTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTAAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9941.46 Da        Isoelectric Point: 7.0146

>AT142854 WP_032481064.1 NZ_CP045857:c1170658-1170392 [Shewanella chilikensis]
MATKTAPINMRVLPSVRDIIDAAASLKKVDRTVFIQQAALNEAHSILAEQRDFVLEAKAFEAFDNELRANPQTLEGMKDL
FKRKAPWE

Download         Length: 267 bp

>AT142854 NZ_CP060885:2437585-2437851 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTAGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACACTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G7LPD4

Antitoxin

Source ID Structure
AlphaFold DB A0A501XZ00

References