Detailed information of TA system TA142853

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 921866..923011
• Replicon: chromosome
• Accession: NZ_CP045857
• Organism: Shewanella chilikensis strain DC57

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: GII14_RS04265
• Protein ID: WP_165564527.1
• Coordinates: 922265..923011 (+)
• Length: 249 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A7X5Z3H2
• Locus tag: GII14_RS04260
• Protein ID: WP_025011540.1
• Coordinates: 921866..922228 (+)
• Length: 121 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GII14_RS04230	918002..918337	+	336	WP_101052533.1	hypothetical protein	-
GII14_RS04235	918403..918993	+	591	WP_165564524.1	hypothetical protein	-
GII14_RS04240	919057..919221	-	165	WP_157822651.1	hypothetical protein	-
GII14_RS04245	919331..920068	-	738	WP_165564525.1	thioredoxin domain-containing protein	-
GII14_RS04250	920209..920850	-	642	WP_101052696.1	DnaJ domain-containing protein	-
GII14_RS04255	920981..921634	-	654	WP_165564526.1	oxygen-insensitive NAD(P)H nitroreductase	-
GII14_RS04260	921866..922228	+	363	WP_025011540.1	MbcA/ParS/Xre antitoxin family protein	Antitoxin
GII14_RS04265	922265..923011	+	747	WP_165564527.1	RES family NAD+ phosphorylase	Toxin
GII14_RS04270	923026..924591	-	1566	WP_165564528.1	hypothetical protein	-
GII14_RS04275	924690..925415	-	726	WP_165564529.1	amino acid ABC transporter ATP-binding protein	-
GII14_RS04280	925408..926085	-	678	WP_101052519.1	amino acid ABC transporter permease	-
GII14_RS04285	926092..926817	-	726	WP_165564530.1	basic amino acid ABC transporter substrate-binding protein	-
GII14_RS04290	927228..927794	+	567	WP_101052515.1	hypoxanthine phosphoribosyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (55-206)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (69-118)

Sequences

Toxin

Protein

• Length: 249 a.a.
• Molecular weight: 28809.65 Da
• Isoelectric Point: 5.1391

>T142853 WP_165564527.1 NZ_CP045857:922265-923011 [Shewanella chilikensis]
MDFSALEPQDFFPRHYFGRGYRLVESQEEAATLSLVDDFDEQMLLESLLDEVKPPYRSGTEHLHYLLKTPFRYPPLRHGS
RFGSITMESFFYASESWQTCLAEVAYYRFVFMADMLEPYLEPLRSEHMLYSVDINARDCADLTLLQGQGVQQQLTHKSSY
AYTQALGAWLLQQQAQMIRYTSARAEKGVNLALHDPLVLLSTEPQECEYWLCQSSADKVAFSRRNSRSMPLTWFLKDFLR
DGQLPRPA

Nucleotide

• Length: 747 bp

>T142853 NZ_CP060885:2106389-2106492 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 121 a.a.
• Molecular weight: 13125.14 Da
• Isoelectric Point: 10.4675

>AT142853 WP_025011540.1 NZ_CP045857:921866-922228 [Shewanella chilikensis]
MNTLEKANAAEVLFKAFSNACSELQLTQAEASRIIGVNPSTLSRNSGKGFKPDSKQGELQLQLIRLYRSLYAIAGGEKAF
MRHWLNSPNKALNGTPKTLLQTVVGLVSVNQYLDAMRGKV

Nucleotide

• Length: 363 bp

>AT142853 NZ_CP060885:c2106530-2106259 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Structures

Antitoxin

• AlphaFold DB: A0A7X5Z3H2