Detailed information of TA system TA142851

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 3920749..3921284
• Replicon: chromosome
• Accession: NZ_CP045854
• Organism: Agrobacterium sp. MA01

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: GH983_RS18755
• Protein ID: WP_153763218.1
• Coordinates: 3920749..3921039 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: GH983_RS18760
• Protein ID: WP_153763643.1
• Coordinates: 3921036..3921284 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GH983_RS18740	3917637..3918065	+	429	WP_153763217.1	hypothetical protein	-
GH983_RS18745	3918174..3919364	+	1191	WP_054150358.1	multidrug effflux MFS transporter	-
GH983_RS18750	3919419..3920642	-	1224	WP_054150357.1	argininosuccinate synthase	-
GH983_RS18755	3920749..3921039	-	291	WP_153763218.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GH983_RS18760	3921036..3921284	-	249	WP_153763643.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
GH983_RS18765	3921386..3922249	+	864	WP_153763219.1	SDR family NAD(P)-dependent oxidoreductase	-
GH983_RS18770	3922324..3922965	+	642	WP_054150355.1	LysE family translocator	-
GH983_RS18775	3922999..3924237	-	1239	WP_153763220.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
GH983_RS18780	3924475..3924978	-	504	WP_054150436.1	hypothetical protein	-
GH983_RS18785	3925243..3925623	-	381	WP_054150354.1	DUF1232 domain-containing protein	-
GH983_RS18790	3925693..3925995	-	303	WP_054150353.1	4a-hydroxytetrahydrobiopterin dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Antitoxin ParD (5-72)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11277.15 Da
• Isoelectric Point: 10.4756

>T142851 WP_153763218.1 NZ_CP045854:c3921039-3920749 [Agrobacterium sp. MA01]
MKPLIVSPRAAHDLDALFDYTEERWGLDQAIAYTLGIRRNLQEICGGRRYGRKIPGLRKAYLSLAYQSHYLIYRETSHSI
VLIRILHRRMNIGRHL

Nucleotide

• Length: 291 bp

>T142851 NZ_CP060885:1844040-1844294 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAGCATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8815.73 Da
• Isoelectric Point: 3.9544

>AT142851 WP_153763643.1 NZ_CP045854:c3921284-3921036 [Agrobacterium sp. MA01]
MNKVTTVTVSGELAEFIEAKISAGDYASEAEVIEAALALLRDEVDGLAAIQAAIDEGEASGQPQPFDFDEFIDRKRRRSA
AE

Nucleotide

• Length: 249 bp

>AT142851 NZ_CP060885:1843792-1844043 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA