Detailed information of TA system TA142850

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2932371..2932972
• Replicon: chromosome
• Accession: NZ_CP045854
• Organism: Agrobacterium sp. MA01

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: GH983_RS14240
• Protein ID: WP_153762737.1
• Coordinates: 2932371..2932553 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: GH983_RS14245
• Protein ID: WP_153762738.1
• Coordinates: 2932574..2932972 (+)
• Length: 133 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GH983_RS14220	2928383..2930233	+	1851	WP_153762733.1	M3 family oligoendopeptidase	-
GH983_RS14225	2930253..2931416	+	1164	WP_153762734.1	aminodeoxychorismate synthase component I	-
GH983_RS14230	2931401..2932021	+	621	WP_153762735.1	aminotransferase class IV family protein	-
GH983_RS14235	2932030..2932314	+	285	WP_153762736.1	GTP cyclohydrolase	-
GH983_RS14240	2932371..2932553	+	183	WP_153762737.1	type II toxin-antitoxin system HicA family toxin	Toxin
GH983_RS14245	2932574..2932972	+	399	WP_153762738.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
GH983_RS14250	2932972..2933838	+	867	WP_153763614.1	DUF3445 domain-containing protein	-
GH983_RS14255	2933975..2935417	+	1443	WP_153762739.1	homospermidine synthase	-
GH983_RS14260	2935604..2935966	+	363	WP_054148231.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-124)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6643.85 Da
• Isoelectric Point: 11.0889

>T142850 WP_153762737.1 NZ_CP045854:2932371-2932553 [Agrobacterium sp. MA01]
MEKDSRKIIQRLKAEGYELVSVSGSHHKLRKGGKTIIVPHPKKDLPLGTARAIAKQAGWI

Nucleotide

• Length: 183 bp

>T142850 NZ_CP060885:1843792-1844043 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Protein

• Length: 133 a.a.
• Molecular weight: 14659.55 Da
• Isoelectric Point: 4.4008

>AT142850 WP_153762738.1 NZ_CP045854:2932574-2932972 [Agrobacterium sp. MA01]
MRYYVALVHKDLESAYGISFPDLPTVFSAADRDEDLVINAIEALRLWAEDEELPVPSSHQDIVERSDVRDELAAGAFLIR
VPLIEDDTRTVRANITMEAGTLAAIDQVAKQRGLTRSAFLASCARKEIERSA

Nucleotide

• Length: 399 bp

>AT142850 NZ_CP060885:1844040-1844294 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAGCATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA