Detailed information of TA system TA142844

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 703129..703672
• Replicon: chromosome
• Accession: NZ_CP045854
• Organism: Agrobacterium sp. MA01

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: GH983_RS03255
• Protein ID: WP_153761600.1
• Coordinates: 703373..703672 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A0N0JM82
• Locus tag: GH983_RS03250
• Protein ID: WP_054148857.1
• Coordinates: 703129..703380 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GH983_RS03240	698764..700698	+	1935	WP_153761598.1	DUF2207 domain-containing protein	-
GH983_RS03245	700870..703023	+	2154	WP_153761599.1	glycine--tRNA ligase subunit beta	-
GH983_RS03250	703129..703380	+	252	WP_054148857.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
GH983_RS03255	703373..703672	+	300	WP_153761600.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GH983_RS03260	703669..704172	+	504	WP_153761601.1	DUF523 domain-containing protein	-
GH983_RS03265	704231..706051	-	1821	WP_153761602.1	cache domain-containing protein	-
GH983_RS03270	706327..706776	-	450	WP_153761603.1	hypothetical protein	-
GH983_RS03275	706902..708173	-	1272	WP_153761604.1	phosphoribosylamine--glycine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-93)

Antitoxin

• Antitoxin ParD (1-80)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11396.93 Da
• Isoelectric Point: 5.6444

>T142844 WP_153761600.1 NZ_CP045854:703373-703672 [Agrobacterium sp. MA01]
VAEIRLSPAARQDFLEIGDYTRDRWSEAQAERYLRQILAMIGEIGVHPFSGSEVPSLRSGYRRSRCGSHLIFYVILEDSM
VEVVRIIHERADYLGKLDD

Nucleotide

• Length: 300 bp

>T142844 NZ_CP060885:c664213-663749 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9351.44 Da
• Isoelectric Point: 4.2472

>AT142844 WP_054148857.1 NZ_CP045854:703129-703380 [Agrobacterium sp. MA01]
MNKPVQVTIAEPFDSFIDAQLESGQFKSAQEVVEAGLQLLKEEQARVEWLRNALIEGENSGPSVSFDPEDLMTSVRERWK
SRG

Nucleotide

• Length: 252 bp

>AT142844 NZ_CP060885:c664548-664213 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A0N0JM82