Detailed information of TA system TA142843

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): CapRel-ATcapRel/-
• Location: 3543429..3544309
• Replicon: chromosome
• Accession: NZ_CP045851
• Organism: Actinomarinicola tropica strain SCSIO 58843

Toxin (Protein)

• Gene name: capRel
• Uniprot ID: -
• Locus tag: GH723_RS17480
• Protein ID: WP_195210401.1
• Coordinates: 3543429..3544061 (+)
• Length: 211 a.a.

Antitoxin (Protein)

• Gene name: ATcapRel
• Uniprot ID: -
• Locus tag: GH723_RS17485
• Protein ID: WP_153760845.1
• Coordinates: 3544058..3544309 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GH723_RS17465	3539078..3541816	+	2739	WP_195210400.1	conjugative relaxase TrwC/TraI family protein	-
GH723_RS17470	3541806..3542870	-	1065	WP_153760843.1	site-specific integrase	-
GH723_RS17475	3543042..3543215	-	174	WP_153761277.1	helix-turn-helix domain-containing protein	-
GH723_RS17480	3543429..3544061	+	633	WP_195210401.1	RelA/SpoT domain-containing protein	Toxin
GH723_RS17485	3544058..3544309	+	252	WP_153760845.1	hypothetical protein	Antitoxin
GH723_RS17490	3544734..3546392	-	1659	WP_153760846.1	hypothetical protein	-
GH723_RS17495	3546389..3546886	-	498	WP_195210402.1	sigma-70 family RNA polymerase sigma factor	-
GH723_RS17500	3547174..3547668	-	495	WP_153760848.1	hypothetical protein	-
GH723_RS18580	3547937..3548086	-	150	WP_195210403.1	hypothetical protein	-
GH723_RS17505	3548178..3548654	+	477	WP_153760849.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	3534091..3544527	10436

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RelA/SpoT (43-143)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 211 a.a.
• Molecular weight: 23349.97 Da
• Isoelectric Point: 9.5325

>T142843 WP_195210401.1 NZ_CP045851:3543429-3544061 [Actinomarinicola tropica]
MSVSPEEHERALAVLLAHRAAHRLPLTKATMGLRSVVKTEHCVVEVSQRLKRVPTIIEKLTVREPTMQLANMQDIGGCRA
VLDSIDEVRRVQRRLSKNRPPLRVSDYISESRRSGYRGVHVVVQYDGRPIEVQLRTQVMHEWAITVERLGGRLGEDLKSG
YGPPEVLDLLGGISEVMAIEEQGGVVPTEALTRLSSLREAALPFLGGGHR

Nucleotide

• Length: 633 bp

>T142843 NZ_CP060885:348394-348921 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATAAAAAAGCCCATACGTTTTATCAATCGCTGGGCTTTATCCCGTTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATCGAACTGCTTTTCACACAGAGCGATTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9144.11 Da
• Isoelectric Point: 4.4055

>AT142843 WP_153760845.1 NZ_CP045851:3544058-3544309 [Actinomarinicola tropica]
MTDRIQHFLLVFDHQAGSLIQTREYGEDADAAIAAYAATEAEFGDRKDIEVVLIGSDSFETVKRTHANYFDGSVSVSKYL
AGI

Nucleotide

• Length: 252 bp

>AT142843 NZ_CP060885:348121-348387 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCTGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA