Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 844381..845044 Replicon chromosome
Accession NZ_CP045843
Organism Kluyvera intermedia strain HR2

Toxin (Protein)


Gene name cptA Uniprot ID A0A3S4EYA3
Locus tag GHC38_RS04075 Protein ID WP_062773047.1
Coordinates 844628..845044 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A3S4FV25
Locus tag GHC38_RS04070 Protein ID WP_062773044.1
Coordinates 844381..844647 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GHC38_RS04045 839513..840946 - 1434 WP_062773028.1 6-phospho-beta-glucosidase BglA -
GHC38_RS04050 841067..841840 - 774 WP_126441028.1 MurR/RpiR family transcriptional regulator -
GHC38_RS04055 841847..842161 + 315 WP_062773034.1 N(4)-acetylcytidine aminohydrolase -
GHC38_RS04060 842320..842982 + 663 WP_153742212.1 hemolysin III family protein -
GHC38_RS04065 843149..844132 - 984 WP_153742213.1 tRNA-modifying protein YgfZ -
GHC38_RS04070 844381..844647 + 267 WP_062773044.1 FAD assembly factor SdhE Antitoxin
GHC38_RS04075 844628..845044 + 417 WP_062773047.1 protein YgfX Toxin
GHC38_RS04080 845041..845562 - 522 WP_153744004.1 flavodoxin FldB -
GHC38_RS04085 845665..846561 + 897 WP_062773053.1 site-specific tyrosine recombinase XerD -
GHC38_RS04090 846583..847296 + 714 WP_062773056.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GHC38_RS04095 847302..849035 + 1734 WP_062773059.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 16416.32 Da        Isoelectric Point: 11.6889

>T142817 WP_062773047.1 NZ_CP045843:844628-845044 [Kluyvera intermedia]
VVLWQSDLRVSWRSQWLSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSLVVFDCVRSQRRIHSHQGEIKLLMDSRLRWRNQ
EWDILGTPWMLSSGMMLRIRRCDGGRRQHLWLAADSMNAQEWRDLRRILLQQPAPGQH

Download         Length: 417 bp

>T142817 NZ_CP060874:89282-89698 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10507.00 Da        Isoelectric Point: 5.6125

>AT142817 WP_062773044.1 NZ_CP045843:844381-844647 [Kluyvera intermedia]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDEDKTVFIRLLECDDPDLFNWLMNHGKPANADFQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT142817 NZ_CP060874:89055-89285 [Escherichia coli]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S4EYA3

Antitoxin

Source ID Structure
AlphaFold DB A0A3S4FV25

References