Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-RelB |
Location | 4366735..4367251 | Replicon | chromosome |
Accession | NZ_CP045840 | ||
Organism | Citrobacter sp. S40-1-2 |
Toxin (Protein)
Gene name | relE | Uniprot ID | A0A6H3ATC4 |
Locus tag | GHC23_RS20755 | Protein ID | WP_048227188.1 |
Coordinates | 4366735..4367019 (-) | Length | 95 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | A0A6H3AWC7 |
Locus tag | GHC23_RS20760 | Protein ID | WP_003830370.1 |
Coordinates | 4367009..4367251 (-) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GHC23_RS20740 | 4361946..4363598 | + | 1653 | WP_153753849.1 | alpha,alpha-phosphotrehalase | - |
GHC23_RS20745 | 4364008..4366146 | + | 2139 | WP_003830363.1 | anaerobic ribonucleoside-triphosphate reductase | - |
GHC23_RS20750 | 4366267..4366731 | + | 465 | WP_048227187.1 | anaerobic ribonucleoside-triphosphate reductase-activating protein | - |
GHC23_RS20755 | 4366735..4367019 | - | 285 | WP_048227188.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
GHC23_RS20760 | 4367009..4367251 | - | 243 | WP_003830370.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
GHC23_RS20765 | 4367329..4369242 | - | 1914 | WP_153753850.1 | BglG family transcription antiterminator | - |
GHC23_RS20770 | 4369264..4370004 | - | 741 | WP_071446755.1 | KDGP aldolase family protein | - |
GHC23_RS20775 | 4370001..4371119 | - | 1119 | WP_153753851.1 | DgaE family pyridoxal phosphate-dependent ammonia lyase | - |
GHC23_RS20780 | 4371103..4372236 | - | 1134 | WP_008786044.1 | amidohydrolase/deacetylase family metallohydrolase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 95 a.a. Molecular weight: 10918.71 Da Isoelectric Point: 10.0482
>T142811 WP_048227188.1 NZ_CP045840:c4367019-4366735 [Citrobacter sp. S40-1-2]
MTYELEFDPRALKEWHKLGDTVKTQFKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVVVFVVAVGK
REHSAVYHDANKRL
MTYELEFDPRALKEWHKLGDTVKTQFKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVVVFVVAVGK
REHSAVYHDANKRL
Download Length: 285 bp
>T142811 NZ_CP060873:2720280-2720387 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8945.35 Da Isoelectric Point: 5.0651
>AT142811 WP_003830370.1 NZ_CP045840:c4367251-4367009 [Citrobacter sp. S40-1-2]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLASPQKGIKVSLDDL
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLASPQKGIKVSLDDL
Download Length: 243 bp
>AT142811 NZ_CP060873:c2720233-2720167 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A6H3ATC4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A6H3AWC7 |