Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4212887..4213463 Replicon chromosome
Accession NZ_CP045840
Organism Citrobacter sp. S40-1-2

Toxin (Protein)


Gene name shpA Uniprot ID -
Locus tag GHC23_RS20060 Protein ID WP_153753781.1
Coordinates 4213176..4213463 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID -
Locus tag GHC23_RS20055 Protein ID WP_153753780.1
Coordinates 4212887..4213189 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GHC23_RS20035 4208575..4209117 + 543 WP_003830032.1 hypothetical protein -
GHC23_RS20040 4209407..4211557 + 2151 WP_003830033.1 pyruvate/proton symporter BtsT -
GHC23_RS20045 4211608..4211802 + 195 WP_003830038.1 YbdD/YjiX family protein -
GHC23_RS20050 4211815..4212771 + 957 WP_153753779.1 GTPase -
GHC23_RS20055 4212887..4213189 - 303 WP_153753780.1 BrnA antitoxin family protein Antitoxin
GHC23_RS20060 4213176..4213463 - 288 WP_153753781.1 BrnT family toxin Toxin
GHC23_RS20065 4213817..4216162 + 2346 WP_153753782.1 type I restriction-modification system subunit M -
GHC23_RS20070 4216162..4217472 + 1311 WP_153753783.1 restriction endonuclease subunit S -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11193.64 Da        Isoelectric Point: 8.1209

>T142810 WP_153753781.1 NZ_CP045840:c4213463-4213176 [Citrobacter sp. S40-1-2]
MPMEFEWGANKAQSNHRKHGVRFEDAVLVFDDPRHMSRQDRYENGEYRWQTIGIVHCIVVILVAHSVRFESGVEVIRIIS
ARKADSKERNRYEHG

Download         Length: 288 bp

>T142810 NZ_CP060873:2427746-2429068 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CAGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTAACGTTATTACCCGAAAA
TGAAACCATAACGCGCCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGGCTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTTAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAAGATATGTGTCAGACATTCGGTTTACCTTCATCTGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCGTTTTTGATGGGGTCCAGCGAGGCGCTTCGCGATCGTTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTAAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11516.07 Da        Isoelectric Point: 9.5646

>AT142810 WP_153753780.1 NZ_CP045840:c4213189-4212887 [Citrobacter sp. S40-1-2]
MSMVKHKRGSVSALSAQHEAELKALANKPDDDIDYSDIPVTEDEQWSEANRSKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT142810 NZ_CP060873:2427480-2427746 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTAGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACACTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References