Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 3662018..3662638 | Replicon | chromosome |
Accession | NZ_CP045840 | ||
Organism | Citrobacter sp. S40-1-2 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | R8WYV2 |
Locus tag | GHC23_RS17545 | Protein ID | WP_002892050.1 |
Coordinates | 3662420..3662638 (+) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | R8WZW8 |
Locus tag | GHC23_RS17540 | Protein ID | WP_003021733.1 |
Coordinates | 3662018..3662392 (+) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GHC23_RS17530 | 3657164..3658357 | + | 1194 | WP_020996573.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
GHC23_RS17535 | 3658380..3661529 | + | 3150 | WP_008783964.1 | multidrug efflux RND transporter permease subunit | - |
GHC23_RS17540 | 3662018..3662392 | + | 375 | WP_003021733.1 | Hha toxicity modulator TomB | Antitoxin |
GHC23_RS17545 | 3662420..3662638 | + | 219 | WP_002892050.1 | hemolysin expression modulator Hha | Toxin |
GHC23_RS17550 | 3662820..3663371 | + | 552 | WP_003835924.1 | maltose O-acetyltransferase | - |
GHC23_RS17555 | 3663488..3663958 | + | 471 | WP_020996574.1 | YlaC family protein | - |
GHC23_RS17560 | 3664036..3664176 | - | 141 | WP_005125190.1 | type B 50S ribosomal protein L36 | - |
GHC23_RS17565 | 3664178..3664438 | - | 261 | WP_153753648.1 | type B 50S ribosomal protein L31 | - |
GHC23_RS17570 | 3664627..3666180 | + | 1554 | WP_153753649.1 | EAL domain-containing protein | - |
GHC23_RS17575 | 3666232..3666585 | - | 354 | WP_008783959.1 | DUF1428 family protein | - |
GHC23_RS17580 | 3666650..3667279 | - | 630 | WP_032942547.1 | membrane protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T142809 WP_002892050.1 NZ_CP045840:3662420-3662638 [Citrobacter sp. S40-1-2]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
Download Length: 219 bp
>T142809 NZ_CP060873:2096284-2096387 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT
Antitoxin
Download Length: 125 a.a. Molecular weight: 14427.23 Da Isoelectric Point: 5.5653
>AT142809 WP_003021733.1 NZ_CP045840:3662018-3662392 [Citrobacter sp. S40-1-2]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC
Download Length: 375 bp
>AT142809 NZ_CP060873:c2096425-2096154 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2P8K6F2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | R8WZW8 |