Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-DnaT |
Location | 46856..47378 | Replicon | plasmid pH12-2 |
Accession | NZ_CP045839 | ||
Organism | Citrobacter sp. H12-3-2 |
Toxin (Protein)
Gene name | relE | Uniprot ID | D0QMR1 |
Locus tag | GHC22_RS24320 | Protein ID | WP_000220561.1 |
Coordinates | 46856..47137 (-) | Length | 94 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | G3CAG1 |
Locus tag | GHC22_RS24325 | Protein ID | WP_000121743.1 |
Coordinates | 47127..47378 (-) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GHC22_RS24285 | 41892..43391 | - | 1500 | Protein_46 | Tn3 family transposase | - |
GHC22_RS24290 | 43477..44229 | + | 753 | WP_000602738.1 | IS6 family transposase | - |
GHC22_RS24295 | 44280..44645 | - | 366 | Protein_48 | AAC(3) family N-acetyltransferase | - |
GHC22_RS24300 | 44651..44842 | - | 192 | Protein_49 | hypothetical protein | - |
GHC22_RS24305 | 44962..45150 | + | 189 | WP_000957857.1 | hypothetical protein | - |
GHC22_RS24310 | 45160..46359 | + | 1200 | WP_112901278.1 | IS91 family transposase | - |
GHC22_RS24315 | 46525..46617 | + | 93 | Protein_52 | IS6 family transposase | - |
GHC22_RS24320 | 46856..47137 | - | 282 | WP_000220561.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
GHC22_RS24325 | 47127..47378 | - | 252 | WP_000121743.1 | plasmid stabilization protein | Antitoxin |
GHC22_RS24330 | 48613..49452 | + | 840 | WP_024129959.1 | replication initiation protein | - |
GHC22_RS24335 | 49473..50315 | + | 843 | WP_000435064.1 | replication initiation protein | - |
GHC22_RS24340 | 50319..50765 | + | 447 | WP_001074384.1 | hypothetical protein | - |
GHC22_RS24345 | 50833..51255 | + | 423 | WP_179292036.1 | DNA distortion polypeptide 3 | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | dfrA12 / aadA2 / qacE / sul1 / rmtB / blaTEM-1B / floR / tet(A) / aph(6)-Id / aph(3'')-Ib / sul2 / ARR-3 / catB3 / blaOXA-1 / aac(6')-Ib-cr / lnu(F) / qnrS1 | - | 1..84545 | 84545 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 11023.86 Da Isoelectric Point: 10.5938
>T142794 WP_000220561.1 NZ_CP045839:c47137-46856 [Citrobacter sp. H12-3-2]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADMR
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADMR
Download Length: 282 bp
>T142794 NZ_CP060868:c133937-133539 [Escherichia coli]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTTACGATAAAGAACAAACCCGCCAGCGTCAGGGAGCGTTTTAA
CCTTAACCAGGGGAGAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGATGTTCTGGATTACGACGCCGCTGCAGCCATACACACC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCTG
TCGGGGGCTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGGCGGCCTGAGAATTGAAGACTGGAGCTGA
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTTACGATAAAGAACAAACCCGCCAGCGTCAGGGAGCGTTTTAA
CCTTAACCAGGGGAGAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGATGTTCTGGATTACGACGCCGCTGCAGCCATACACACC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCTG
TCGGGGGCTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGGCGGCCTGAGAATTGAAGACTGGAGCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9194.43 Da Isoelectric Point: 4.1683
>AT142794 WP_000121743.1 NZ_CP045839:c47378-47127 [Citrobacter sp. H12-3-2]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL
Download Length: 252 bp
>AT142794 NZ_CP060868:c134164-133937 [Escherichia coli]
ATGGAAACCACCGTATTTCTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTATCGGACGAACCCGACTCATTACGCCAGCCGGAGAGACATGGGACGAATGGTTCGACGGAC
ACAGCGTCAGCGCCGATTTTATGGATAACAGGGAACAGCCCGGCATGCAGGAACGGGAGTCATTCTGA
ATGGAAACCACCGTATTTCTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTATCGGACGAACCCGACTCATTACGCCAGCCGGAGAGACATGGGACGAATGGTTCGACGGAC
ACAGCGTCAGCGCCGATTTTATGGATAACAGGGAACAGCCCGGCATGCAGGAACGGGAGTCATTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3S5I302 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3S5I301 |