Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4366735..4367251 Replicon chromosome
Accession NZ_CP045837
Organism Citrobacter sp. H12-3-2

Toxin (Protein)


Gene name relE Uniprot ID A0A6H3ATC4
Locus tag GHC22_RS20755 Protein ID WP_048227188.1
Coordinates 4366735..4367019 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A6H3AWC7
Locus tag GHC22_RS20760 Protein ID WP_003830370.1
Coordinates 4367009..4367251 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GHC22_RS20740 4361946..4363598 + 1653 WP_153753849.1 alpha,alpha-phosphotrehalase -
GHC22_RS20745 4364008..4366146 + 2139 WP_003830363.1 anaerobic ribonucleoside-triphosphate reductase -
GHC22_RS20750 4366267..4366731 + 465 WP_048227187.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
GHC22_RS20755 4366735..4367019 - 285 WP_048227188.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GHC22_RS20760 4367009..4367251 - 243 WP_003830370.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GHC22_RS20765 4367329..4369242 - 1914 WP_153753850.1 BglG family transcription antiterminator -
GHC22_RS20770 4369264..4370004 - 741 WP_071446755.1 KDGP aldolase family protein -
GHC22_RS20775 4370001..4371119 - 1119 WP_153753851.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
GHC22_RS20780 4371103..4372236 - 1134 WP_008786044.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-65)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10918.71 Da        Isoelectric Point: 10.0482

>T142790 WP_048227188.1 NZ_CP045837:c4367019-4366735 [Citrobacter sp. H12-3-2]
MTYELEFDPRALKEWHKLGDTVKTQFKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVVVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T142790 NZ_CP060867:4062686-4063150 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGTTCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8945.35 Da        Isoelectric Point: 5.0651

>AT142790 WP_003830370.1 NZ_CP045837:c4367251-4367009 [Citrobacter sp. H12-3-2]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLASPQKGIKVSLDDL

Download         Length: 243 bp

>AT142790 NZ_CP060867:4062351-4062686 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6H3ATC4

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AWC7

References