Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2539192..2539928 Replicon chromosome
Accession NZ_CP045837
Organism Citrobacter sp. H12-3-2

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag GHC22_RS12115 Protein ID WP_079934035.1
Coordinates 2539446..2539928 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag GHC22_RS12110 Protein ID WP_008784769.1
Coordinates 2539192..2539458 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GHC22_RS12090 2534255..2535442 + 1188 WP_153753069.1 outer membrane protein transport protein -
GHC22_RS12095 2535680..2536309 + 630 WP_008784772.1 winged helix-turn-helix transcriptional regulator -
GHC22_RS12100 2536415..2536801 - 387 WP_111465586.1 hypothetical protein -
GHC22_RS12105 2537056..2539038 + 1983 WP_153753071.1 MBL fold metallo-hydrolase -
GHC22_RS12110 2539192..2539458 + 267 WP_008784769.1 DUF1778 domain-containing protein Antitoxin
GHC22_RS12115 2539446..2539928 + 483 WP_079934035.1 GNAT family N-acetyltransferase Toxin
GHC22_RS12120 2540182..2541258 + 1077 WP_161799729.1 hypothetical protein -
GHC22_RS12125 2542033..2542968 + 936 WP_047359049.1 hypothetical protein -
GHC22_RS12130 2543239..2543643 + 405 WP_153753073.1 hypothetical protein -
GHC22_RS12135 2543640..2543975 + 336 WP_194841944.1 hypothetical protein -
GHC22_RS12140 2543992..2544351 + 360 WP_045269654.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2536415..2546073 9658


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(80-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17660.55 Da        Isoelectric Point: 10.1016

>T142787 WP_079934035.1 NZ_CP045837:2539446-2539928 [Citrobacter sp. H12-3-2]
VGFVTAPEPLTHIHQLAEFVSGEIVLDDWLKQKGLKNQALGAARTFVVCKTDTRKVAGFYSLATGSVNRTEVTGNLRRNM
PDPIPVIILARLAVDLSVRGKGLGADLLHDAVLRCYKVAENIGVRAVMVHALTDEAKRFYLHHGFKASQLQERTLFLRLS

Download         Length: 483 bp

>T142787 NZ_CP060867:3878231-3878605 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCCA
CAACTACAGAACGGTGAACAATATCACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10159.65 Da        Isoelectric Point: 4.6558

>AT142787 WP_008784769.1 NZ_CP045837:2539192-2539458 [Citrobacter sp. H12-3-2]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIEMLDAPVAEDPAIRKLL
ARKPQWDL

Download         Length: 267 bp

>AT142787 NZ_CP060867:3877773-3878141 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References