Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
Location | 2539192..2539928 | Replicon | chromosome |
Accession | NZ_CP045837 | ||
Organism | Citrobacter sp. H12-3-2 |
Toxin (Protein)
Gene name | tacT | Uniprot ID | - |
Locus tag | GHC22_RS12115 | Protein ID | WP_079934035.1 |
Coordinates | 2539446..2539928 (+) | Length | 161 a.a. |
Antitoxin (Protein)
Gene name | tacA | Uniprot ID | - |
Locus tag | GHC22_RS12110 | Protein ID | WP_008784769.1 |
Coordinates | 2539192..2539458 (+) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GHC22_RS12090 | 2534255..2535442 | + | 1188 | WP_153753069.1 | outer membrane protein transport protein | - |
GHC22_RS12095 | 2535680..2536309 | + | 630 | WP_008784772.1 | winged helix-turn-helix transcriptional regulator | - |
GHC22_RS12100 | 2536415..2536801 | - | 387 | WP_111465586.1 | hypothetical protein | - |
GHC22_RS12105 | 2537056..2539038 | + | 1983 | WP_153753071.1 | MBL fold metallo-hydrolase | - |
GHC22_RS12110 | 2539192..2539458 | + | 267 | WP_008784769.1 | DUF1778 domain-containing protein | Antitoxin |
GHC22_RS12115 | 2539446..2539928 | + | 483 | WP_079934035.1 | GNAT family N-acetyltransferase | Toxin |
GHC22_RS12120 | 2540182..2541258 | + | 1077 | WP_161799729.1 | hypothetical protein | - |
GHC22_RS12125 | 2542033..2542968 | + | 936 | WP_047359049.1 | hypothetical protein | - |
GHC22_RS12130 | 2543239..2543643 | + | 405 | WP_153753073.1 | hypothetical protein | - |
GHC22_RS12135 | 2543640..2543975 | + | 336 | WP_194841944.1 | hypothetical protein | - |
GHC22_RS12140 | 2543992..2544351 | + | 360 | WP_045269654.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 2536415..2546073 | 9658 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 161 a.a. Molecular weight: 17660.55 Da Isoelectric Point: 10.1016
>T142787 WP_079934035.1 NZ_CP045837:2539446-2539928 [Citrobacter sp. H12-3-2]
VGFVTAPEPLTHIHQLAEFVSGEIVLDDWLKQKGLKNQALGAARTFVVCKTDTRKVAGFYSLATGSVNRTEVTGNLRRNM
PDPIPVIILARLAVDLSVRGKGLGADLLHDAVLRCYKVAENIGVRAVMVHALTDEAKRFYLHHGFKASQLQERTLFLRLS
VGFVTAPEPLTHIHQLAEFVSGEIVLDDWLKQKGLKNQALGAARTFVVCKTDTRKVAGFYSLATGSVNRTEVTGNLRRNM
PDPIPVIILARLAVDLSVRGKGLGADLLHDAVLRCYKVAENIGVRAVMVHALTDEAKRFYLHHGFKASQLQERTLFLRLS
Download Length: 483 bp
>T142787 NZ_CP060867:3878231-3878605 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCCA
CAACTACAGAACGGTGAACAATATCACCCTGGGTAAGTATCCGGAGGCGAAATGA
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCCA
CAACTACAGAACGGTGAACAATATCACCCTGGGTAAGTATCCGGAGGCGAAATGA
Antitoxin
Download Length: 89 a.a. Molecular weight: 10159.65 Da Isoelectric Point: 4.6558
>AT142787 WP_008784769.1 NZ_CP045837:2539192-2539458 [Citrobacter sp. H12-3-2]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIEMLDAPVAEDPAIRKLL
ARKPQWDL
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIEMLDAPVAEDPAIRKLL
ARKPQWDL
Download Length: 267 bp
>AT142787 NZ_CP060867:3877773-3878141 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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