Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ypjF-yeeU/CbtA-CbeA
Location 925817..926517 Replicon chromosome
Accession NZ_CP045837
Organism Citrobacter sp. H12-3-2

Toxin (Protein)


Gene name ypjF Uniprot ID A0A7H4NX47
Locus tag GHC22_RS04530 Protein ID WP_001546951.1
Coordinates 926194..926517 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag GHC22_RS04525 Protein ID WP_049116113.1
Coordinates 925817..926173 (+) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GHC22_RS04495 921769..922662 + 894 WP_048215606.1 50S ribosome-binding GTPase -
GHC22_RS04500 922947..923624 + 678 WP_048215607.1 hypothetical protein -
GHC22_RS04505 923723..924544 + 822 WP_048215608.1 DUF945 domain-containing protein -
GHC22_RS04510 924575..925018 + 444 WP_048215609.1 antirestriction protein -
GHC22_RS04515 925031..925573 + 543 WP_048215610.1 DNA repair protein RadC -
GHC22_RS04520 925570..925791 + 222 WP_047644100.1 DUF987 family protein -
GHC22_RS04525 925817..926173 + 357 WP_049116113.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
GHC22_RS04530 926194..926517 + 324 WP_001546951.1 TA system toxin CbtA family protein Toxin
GHC22_RS04535 926759..927295 - 537 WP_032944886.1 GNAT family N-acetyltransferase -
GHC22_RS04540 928111..930573 + 2463 WP_057067439.1 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-107)

Antitoxin

Antitoxin CbeA

(17-117)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12496.55 Da        Isoelectric Point: 7.1331

>T142777 WP_001546951.1 NZ_CP045837:926194-926517 [Citrobacter sp. H12-3-2]
MKFLPTTNMRAAKPCLSPVTIWQMLLSRLLEQHYGLTLNDTPFCDETVIQEHIDAGITLANAINFLVEKYELVRIDRRGF
SWQEQTPYLTIIDIMRARRDLGLMNRN

Download         Length: 324 bp

>T142777 NZ_CP060867:c1992975-1992868 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 13083.78 Da        Isoelectric Point: 6.2018

>AT142777 WP_049116113.1 NZ_CP045837:925817-926173 [Citrobacter sp. H12-3-2]
MNNHSESGAIPENPPCQQWGLKSTITPCFGARLVQEGDRLHFLADRAGFNGAFSDEHALRLDQAFPLILKQLELILTSGE
LSPRHQHCVTLYHNGLTCEADTLGSCGYVYIAIYPTQR

Download         Length: 357 bp

>AT142777 NZ_CP060867:1993022-1993088 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H4NX47

Antitoxin

Source ID Structure

References