Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 867979..868633 Replicon chromosome
Accession NZ_CP045837
Organism Citrobacter sp. H12-3-2

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag GHC22_RS04185 Protein ID WP_003825515.1
Coordinates 868226..868633 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag GHC22_RS04180 Protein ID WP_003825514.1
Coordinates 867979..868245 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GHC22_RS04155 863134..864567 - 1434 WP_103284743.1 6-phospho-beta-glucosidase BglA -
GHC22_RS04160 864688..865416 - 729 WP_153753956.1 MurR/RpiR family transcriptional regulator -
GHC22_RS04165 865469..865780 + 312 WP_048225466.1 N(4)-acetylcytidine aminohydrolase -
GHC22_RS04170 865944..866606 + 663 WP_071445549.1 hemolysin III family protein -
GHC22_RS04175 866738..867721 - 984 WP_153752296.1 tRNA-modifying protein YgfZ -
GHC22_RS04180 867979..868245 + 267 WP_003825514.1 FAD assembly factor SdhE Antitoxin
GHC22_RS04185 868226..868633 + 408 WP_003825515.1 protein YgfX Toxin
GHC22_RS04190 868735..869256 - 522 WP_003026933.1 flavodoxin FldB -
GHC22_RS04195 869370..870266 + 897 WP_003825519.1 site-specific tyrosine recombinase XerD -
GHC22_RS04200 870290..871003 + 714 WP_003825520.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GHC22_RS04205 871009..872742 + 1734 WP_153752298.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15882.76 Da        Isoelectric Point: 11.3523

>T142776 WP_003825515.1 NZ_CP045837:868226-868633 [Citrobacter sp. H12-3-2]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQG

Download         Length: 408 bp

>T142776 NZ_CP060867:c1992440-1992333 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10615.14 Da        Isoelectric Point: 5.1700

>AT142776 WP_003825514.1 NZ_CP045837:867979-868245 [Citrobacter sp. H12-3-2]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADEQLEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT142776 NZ_CP060867:1992488-1992554 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References