Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 1361..1824 Replicon plasmid pAUSMDU00010541_02
Accession NZ_CP045834
Organism Neisseria gonorrhoeae strain AUSMDU00010541

Toxin (Protein)


Gene name VapD Uniprot ID Q51003
Locus tag GIJ09_RS12090 Protein ID WP_003690225.1
Coordinates 1546..1824 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID Q51002
Locus tag GIJ09_RS12085 Protein ID WP_003690223.1
Coordinates 1361..1546 (+) Length 62 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GIJ09_RS12070 88..870 + 783 WP_010359605.1 replication initiation protein -
GIJ09_RS12075 874..1116 + 243 WP_003690220.1 HTH domain-containing protein -
GIJ09_RS12080 1113..1358 + 246 WP_003690221.1 hypothetical protein -
GIJ09_RS12085 1361..1546 + 186 WP_003690223.1 DUF5397 family protein Antitoxin
GIJ09_RS12090 1546..1824 + 279 WP_003690225.1 endoribonuclease VapD Toxin
GIJ09_RS12095 1802..2071 - 270 WP_003692166.1 hypothetical protein -
GIJ09_RS12100 2103..2744 - 642 WP_010359606.1 protein B -
GIJ09_RS12105 2701..3447 - 747 Protein_7 relaxase/mobilization nuclease domain-containing protein -
GIJ09_RS12110 3432..3623 - 192 WP_003690218.1 plasmid mobilization relaxosome protein MobC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..4197 4197


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(2-60)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10473.89 Da        Isoelectric Point: 6.9726

>T142773 WP_003690225.1 NZ_CP045834:1546-1824 [Neisseria gonorrhoeae]
MYAISFDLVVADTAQNHPKGISQAYADIGYTLRKFGFTRIQGSLYTCQNEDMANLFSAINELKALPWFPSSVRDIRAFRI
EQWSDFTSLVKS

Download         Length: 279 bp

>T142773 NZ_CP060867:c881106-880828 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 62 a.a.        Molecular weight: 6717.54 Da        Isoelectric Point: 4.2641

>AT142773 WP_003690223.1 NZ_CP045834:1361-1546 [Neisseria gonorrhoeae]
MQTTIPTGSIRTFGDYGVMYIVGTPAEQLPDGDWLVNIELPESGEHTQYKLSHIVQDPKAA

Download         Length: 186 bp

>AT142773 NZ_CP060867:c881369-881109 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H5FJI5

Antitoxin

Source ID Structure
AlphaFold DB Q51002

References