142771

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 843547..844202 Replicon chromosome
Accession NZ_CP045832
Organism Neisseria gonorrhoeae strain AUSMDU00010541

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag GIJ09_RS04685 Protein ID WP_003691083.1
Coordinates 843783..844202 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag GIJ09_RS04680 Protein ID WP_003688410.1
Coordinates 843547..843783 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GIJ09_RS04645 838681..838968 + 288 WP_003688407.1 hypothetical protein -
GIJ09_RS04650 839040..840206 + 1167 WP_003688408.1 ADP-forming succinate--CoA ligase subunit beta -
GIJ09_RS04655 840217..841107 + 891 WP_003688409.1 succinate--CoA ligase subunit alpha -
GIJ09_RS04660 841490..841876 - 387 Protein_862 IS110 family transposase -
GIJ09_RS04665 842088..842516 + 429 WP_003701165.1 helix-turn-helix domain-containing protein -
GIJ09_RS04670 842521..843099 + 579 WP_003688041.1 IS3 family transposase -
GIJ09_RS04675 843144..843341 + 198 WP_033910354.1 IS3 family transposase -
GIJ09_RS04680 843547..843783 + 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
GIJ09_RS04685 843783..844202 + 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
GIJ09_RS04690 844351..845805 - 1455 WP_003688412.1 iron-sulfur cluster-binding protein -
GIJ09_RS04695 845802..846503 - 702 WP_003688414.1 lactate utilization protein C -
GIJ09_RS04700 846500..847279 - 780 WP_003688416.1 (Fe-S)-binding protein -
GIJ09_RS04705 847427..848968 + 1542 WP_172587033.1 multidrug efflux MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T142771 WP_003691083.1 NZ_CP045832:843783-844202 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

>T142771 NZ_CP060867:431579-431929 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GTGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTT
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT142771 WP_003688410.1 NZ_CP045832:843547-843783 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp

>AT142771 NZ_CP060867:431334-431585 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
AlphaFold DB Q5F881

References