Detailed information of TA system TA142770

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 651888..652573
• Replicon: chromosome
• Accession: NZ_CP045832
• Organism: Neisseria gonorrhoeae strain AUSMDU00010541

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Q5F6D1
• Locus tag: GIJ09_RS03540
• Protein ID: WP_003689143.1
• Coordinates: 652391..652573 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q5F6D2
• Locus tag: GIJ09_RS03535
• Protein ID: WP_003691454.1
• Coordinates: 651888..652289 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GIJ09_RS03485	647079..647294	-	216	WP_003691538.1	hypothetical protein	-
GIJ09_RS03490	647346..647837	-	492	WP_003691537.1	siphovirus Gp157 family protein	-
GIJ09_RS03495	647834..648016	-	183	WP_003691535.1	hypothetical protein	-
GIJ09_RS03500	648156..648842	-	687	WP_012503754.1	hypothetical protein	-
GIJ09_RS03505	648911..649072	-	162	WP_003702497.1	hypothetical protein	-
GIJ09_RS03510	649069..649344	-	276	WP_050156283.1	hypothetical protein	-
GIJ09_RS03515	649497..649829	-	333	WP_153707855.1	hypothetical protein	-
GIJ09_RS03520	650098..650574	-	477	WP_012504141.1	hypothetical protein	-
GIJ09_RS03525	650607..650807	-	201	WP_003704298.1	hypothetical protein	-
GIJ09_RS03530	651007..651789	+	783	WP_003689146.1	hypothetical protein	-
GIJ09_RS03535	651888..652289	-	402	WP_003691454.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
GIJ09_RS03540	652391..652573	-	183	WP_003689143.1	type II toxin-antitoxin system HicA family toxin	Toxin
GIJ09_RS03545	652743..653561	-	819	WP_012503752.1	DUF3037 domain-containing protein	-
GIJ09_RS03550	653558..654256	-	699	WP_003689139.1	hypothetical protein	-
GIJ09_RS03555	654495..655193	-	699	WP_002212401.1	helix-turn-helix domain-containing protein	-
GIJ09_RS03560	655233..655919	-	687	WP_012503751.1	helix-turn-helix transcriptional regulator	-
GIJ09_RS03565	656084..656269	+	186	WP_048654326.1	helix-turn-helix domain-containing protein	-
GIJ09_RS12165	656271..656471	+	201	WP_012503750.1	hypothetical protein	-
GIJ09_RS03575	656668..657558	+	891	WP_050155708.1	replication protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	634497..679346	44849

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6687.77 Da
• Isoelectric Point: 10.7235

>T142770 WP_003689143.1 NZ_CP045832:c652573-652391 [Neisseria gonorrhoeae]
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK

Nucleotide

• Length: 183 bp

>T142770 NZ_CP060867:329410-329583 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14634.43 Da
• Isoelectric Point: 4.5457

>AT142770 WP_003691454.1 NZ_CP045832:c652289-651888 [Neisseria gonorrhoeae]
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA

Nucleotide

• Length: 402 bp

>AT142770 NZ_CP060867:329086-329382 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Toxin

• AlphaFold DB: Q5F6D1

Antitoxin

• AlphaFold DB: Q5F6D2