Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2463248..2463719 Replicon chromosome
Accession NZ_CP045827
Organism Escherichia coli strain AUSMDU00014361

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag GIJ02_RS12615 Protein ID WP_001303511.1
Coordinates 2463248..2463526 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag GIJ02_RS12620 Protein ID WP_001302048.1
Coordinates 2463528..2463719 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GIJ02_RS12580 2458467..2460911 - 2445 WP_153781610.1 exonuclease -
GIJ02_RS12585 2461004..2461195 - 192 WP_000199474.1 DUF1482 family protein -
GIJ02_RS12590 2461192..2461380 - 189 WP_000449175.1 cell division inhibitor -
GIJ02_RS12600 2461944..2462153 + 210 WP_001133037.1 hypothetical protein -
GIJ02_RS12605 2462154..2462792 - 639 WP_000394548.1 hypothetical protein -
GIJ02_RS12610 2462804..2462956 - 153 WP_000380316.1 DUF1391 family protein -
GIJ02_RS12615 2463248..2463526 - 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GIJ02_RS12620 2463528..2463719 - 192 WP_001302048.1 hypothetical protein Antitoxin
GIJ02_RS12625 2463740..2464111 - 372 WP_001169686.1 hypothetical protein -
GIJ02_RS12630 2464209..2464511 + 303 WP_000172738.1 transcriptional regulator -
GIJ02_RS12635 2464508..2464933 + 426 WP_000693943.1 Rha family transcriptional regulator -
GIJ02_RS12640 2464956..2465924 + 969 WP_153781611.1 helix-turn-helix domain-containing protein -
GIJ02_RS12645 2465931..2466671 + 741 WP_153781612.1 ATP-binding protein -
GIJ02_RS12650 2466701..2467471 + 771 WP_000450861.1 DUF1627 domain-containing protein -
GIJ02_RS12655 2467487..2467879 + 393 WP_001141104.1 DUF977 family protein -
GIJ02_RS12660 2467876..2468172 + 297 WP_001266130.1 DUF4406 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T142747 WP_001303511.1 NZ_CP045827:c2463526-2463248 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

>T142747 NZ_CP060852:2034190-2034293 [Salmonella enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT142747 WP_001302048.1 NZ_CP045827:c2463719-2463528 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp

>AT142747 NZ_CP060852:c2034295-2034152 [Salmonella enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE

Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References