Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2223410..2223891 Replicon chromosome
Accession NZ_CP045827
Organism Escherichia coli strain AUSMDU00014361

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7YS45
Locus tag GIJ02_RS11120 Protein ID WP_014966210.1
Coordinates 2223410..2223700 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID A0A0D7Y007
Locus tag GIJ02_RS11125 Protein ID WP_000100896.1
Coordinates 2223700..2223891 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GIJ02_RS11085 2218767..2219036 - 270 WP_000003742.1 excisionase -
GIJ02_RS11090 2219098..2221569 - 2472 WP_153781589.1 exonuclease -
GIJ02_RS11095 2221662..2221853 - 192 WP_001090200.1 DUF1482 family protein -
GIJ02_RS11100 2221850..2222038 - 189 WP_000449192.1 cell division inhibition protein DicB -
GIJ02_RS11105 2222439..2222603 + 165 WP_001434015.1 hypothetical protein -
GIJ02_RS11110 2222607..2222825 - 219 WP_001171974.1 hypothetical protein -
GIJ02_RS11115 2222985..2223140 - 156 WP_000379575.1 DUF1391 family protein -
GIJ02_RS11120 2223410..2223700 - 291 WP_014966210.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GIJ02_RS11125 2223700..2223891 - 192 WP_000100896.1 hypothetical protein Antitoxin
GIJ02_RS11130 2223909..2224409 - 501 WP_000824162.1 helix-turn-helix transcriptional regulator -
GIJ02_RS11135 2224517..2224792 + 276 WP_001048458.1 helix-turn-helix domain-containing protein -
GIJ02_RS11140 2224776..2225201 + 426 WP_000693918.1 Rha family transcriptional regulator -
GIJ02_RS11145 2225273..2226289 + 1017 WP_001262344.1 hypothetical protein -
GIJ02_RS11150 2226201..2226743 + 543 WP_072130322.1 replication protein -
GIJ02_RS11155 2226777..2227547 + 771 WP_000450649.1 DUF1627 domain-containing protein -
GIJ02_RS11160 2227563..2227985 + 423 WP_001151246.1 DUF977 family protein -
GIJ02_RS11165 2228091..2228303 + 213 WP_000935423.1 hypothetical protein -
GIJ02_RS11170 2228336..2228554 + 219 WP_000209148.1 DUF4014 family protein -
GIJ02_RS11175 2228556..2228819 + 264 WP_000224233.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - espW / espM2 2217680..2284466 66786


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11176.05 Da        Isoelectric Point: 9.9854

>T142744 WP_014966210.1 NZ_CP045827:c2223700-2223410 [Escherichia coli]
MLPILWLPSARDDLRQIVAYIAKENPPAARRLKIRIETSVLSLTEHPYLYPPSERVPSLREIVTHPNYIILYRVTASNIE
IVNVVHSRRQYPNKTC

Download         Length: 291 bp

>T142744 NZ_CP060852:347769-348122 [Salmonella enterica]
ATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGGCATGCCTGATCCTGG
GCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGTGGCTGCTGGCGGCAA
TGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTTATTACGCTGCTGTTT
TTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGCGGCAGGGCGGCTTAC
GCTGGAGCAAATTGTCGTTCGCTTACGCGCCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7033.83 Da        Isoelectric Point: 4.0270

>AT142744 WP_000100896.1 NZ_CP045827:c2223891-2223700 [Escherichia coli]
MSTALSPIISEFETVEQENSYNEWLRTKVAASLSDPRPAIPHDEVMAEMENLIAQLAATNRSE

Download         Length: 192 bp

>AT142744 NZ_CP060852:347535-347756 [Salmonella enterica]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGTGCGGTGACGGGGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D7YS45

Antitoxin

Source ID Structure
AlphaFold DB A0A0D7Y007

References