Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1867819..1868614 Replicon chromosome
Accession NZ_CP045827
Organism Escherichia coli strain AUSMDU00014361

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag GIJ02_RS09185 Protein ID WP_000854914.1
Coordinates 1868240..1868614 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag GIJ02_RS09180 Protein ID WP_001280954.1
Coordinates 1867819..1868193 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GIJ02_RS09150 1863174..1864079 + 906 WP_000203541.1 chemotaxis protein -
GIJ02_RS09155 1864076..1865146 + 1071 WP_000102669.1 patatin-like phospholipase family protein -
GIJ02_RS09160 1865486..1866304 + 819 WP_024219686.1 DUF945 domain-containing protein -
GIJ02_RS09165 1866395..1866880 + 486 WP_153781565.1 antirestriction protein -
GIJ02_RS09170 1866896..1867372 + 477 WP_001186738.1 RadC family protein -
GIJ02_RS09175 1867435..1867656 + 222 WP_001220314.1 DUF987 domain-containing protein -
GIJ02_RS09180 1867819..1868193 + 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
GIJ02_RS09185 1868240..1868614 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
GIJ02_RS09190 1868611..1869102 + 492 WP_000976857.1 hypothetical protein -
GIJ02_RS09195 1869114..1869311 + 198 WP_000839282.1 DUF957 domain-containing protein -
GIJ02_RS09200 1869396..1870238 + 843 WP_001280481.1 DUF4942 domain-containing protein -
GIJ02_RS09210 1870729..1870947 - 219 WP_001040187.1 translation initiation factor IF-1 -
GIJ02_RS09215 1871232..1871936 - 705 WP_153781566.1 leucyl/phenylalanyl-tRNA--protein transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T142743 WP_000854914.1 NZ_CP045827:1868240-1868614 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T142743 NZ_CP060852:213723-214208 [Salmonella enterica]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGGGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT142743 WP_001280954.1 NZ_CP045827:1867819-1868193 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT142743 NZ_CP060852:213448-213735 [Salmonella enterica]
ATGCTATACAAAGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCGGGCTGCCGAGAATGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATTAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References