Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1315468..1316093 Replicon chromosome
Accession NZ_CP045827
Organism Escherichia coli strain AUSMDU00014361

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GIJ02_RS06335 Protein ID WP_000911330.1
Coordinates 1315695..1316093 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag GIJ02_RS06330 Protein ID WP_000450524.1
Coordinates 1315468..1315695 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GIJ02_RS06305 1311271..1311741 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
GIJ02_RS06310 1311741..1312313 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
GIJ02_RS06315 1312459..1313337 + 879 WP_001311023.1 4-hydroxy-tetrahydrodipicolinate synthase -
GIJ02_RS06320 1313354..1314388 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
GIJ02_RS06325 1314601..1315314 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
GIJ02_RS06330 1315468..1315695 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
GIJ02_RS06335 1315695..1316093 + 399 WP_000911330.1 tRNA(fMet)-specific endonuclease VapC Toxin
GIJ02_RS06340 1316240..1317103 + 864 WP_153781538.1 neutral zinc metallopeptidase -
GIJ02_RS06345 1317118..1319133 + 2016 WP_000829332.1 tRNA cytosine(34) acetyltransferase TmcA -
GIJ02_RS06350 1319207..1319905 + 699 WP_024219587.1 esterase -
GIJ02_RS06355 1320015..1320215 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T142742 WP_000911330.1 NZ_CP045827:1315695-1316093 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T142742 NZ_CP060849:c3894359-3894256 [Salmonella enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT142742 WP_000450524.1 NZ_CP045827:1315468-1315695 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT142742 NZ_CP060849:3894254-3894397 [Salmonella enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References