142735

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1434366..1435282 Replicon chromosome
Accession NZ_CP045825
Organism Bacillus subtilis strain 75

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag GII77_RS07680 Protein ID WP_015252263.1
Coordinates 1434536..1435282 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag GII77_RS07675 Protein ID WP_003232646.1
Coordinates 1434366..1434536 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GII77_RS07640 1431226..1431555 + 330 WP_015252268.1 XkdW family protein -
GII77_RS07645 1431552..1431716 + 165 WP_015252267.1 XkdX family protein -
GII77_RS07650 1431763..1432602 + 840 WP_015252266.1 phage-like element PBSX protein XepA -
GII77_RS07655 1432655..1432924 + 270 WP_015252265.1 hemolysin XhlA family protein -
GII77_RS07660 1432937..1433200 + 264 WP_003232653.1 phage holin -
GII77_RS07665 1433213..1434106 + 894 WP_014479567.1 N-acetylmuramoyl-L-alanine amidase -
GII77_RS07670 1434143..1434280 - 138 WP_003232648.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
GII77_RS07675 1434366..1434536 - 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
GII77_RS07680 1434536..1435282 - 747 WP_015252263.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
GII77_RS07685 1435392..1436393 - 1002 WP_003232642.1 inorganic phosphate transporter -
GII77_RS07690 1436406..1437023 - 618 WP_003218470.1 DUF47 domain-containing protein -
GII77_RS07695 1437299..1438615 - 1317 WP_015252262.1 serine/threonine exchanger -
GII77_RS07700 1439004..1439954 + 951 WP_015252261.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29060.56 Da        Isoelectric Point: 4.7741

>T142735 WP_015252263.1 NZ_CP045825:c1435282-1434536 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNKMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

>T142735 NZ_CP060849:c882742-882389 [Salmonella enterica]
ATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGGCATGCCTGATCCTGG
GCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGTGGCTGCTGGCGGCAA
TGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTTATTACGCTGCTGTTT
TTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGCGGCAGGGCGGCTTAC
GCTGGAGCAAATTGTCGTTCGCTTACGCGCCTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT142735 WP_003232646.1 NZ_CP045825:c1434536-1434366 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp

>AT142735 NZ_CP060849:c882976-882755 [Salmonella enterica]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGTGCGGTGACGGGGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3O6Q
AlphaFold DB G4EXD8

References