Detailed information of TA system TA142734

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PhRel2-ATphRel2/DUF4065(antitoxin)
• Location: 680588..682044
• Replicon: chromosome
• Accession: NZ_CP045825
• Organism: Bacillus subtilis strain 75

Toxin (Protein)

• Gene name: phRel2
• Uniprot ID: -
• Locus tag: GII77_RS03660
• Protein ID: WP_153952055.1
• Coordinates: 680588..681289 (+)
• Length: 234 a.a.

Antitoxin (Protein)

• Gene name: ATphRel2
• Uniprot ID: -
• Locus tag: GII77_RS03665
• Protein ID: WP_153952056.1
• Coordinates: 681295..682044 (+)
• Length: 250 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GII77_RS03610	675797..676201	+	405	WP_064911566.1	hypothetical protein	-
GII77_RS03615	676362..676532	+	171	WP_121591683.1	XkdX family protein	-
GII77_RS03620	676544..676801	+	258	WP_153952052.1	hypothetical protein	-
GII77_RS03625	676888..677157	+	270	WP_080348108.1	hemolysin XhlA family protein	-
GII77_RS03630	677173..677436	+	264	WP_153952053.1	phage holin	-
GII77_RS03635	677489..678454	+	966	WP_128737602.1	N-acetylmuramoyl-L-alanine amidase	-
GII77_RS03640	678495..679010	-	516	WP_095714688.1	hypothetical protein	-
GII77_RS21475	679711..679848	+	138	WP_194943391.1	hypothetical protein	-
GII77_RS03650	679911..680120	+	210	WP_194943396.1	hypothetical protein	-
GII77_RS03655	680098..680328	+	231	WP_153952054.1	DNA-binding protein	-
GII77_RS03660	680588..681289	+	702	WP_153952055.1	hypothetical protein	Toxin
GII77_RS03665	681295..682044	+	750	WP_153952056.1	DUF4065 domain-containing protein	Antitoxin
GII77_RS03670	682073..682264	-	192	WP_153952057.1	hypothetical protein	-
GII77_RS03680	683187..684182	+	996	WP_048655027.1	alpha/beta hydrolase family protein	-
GII77_RS03685	684282..686771	-	2490	WP_015252676.1	glucitol operon transcriptional regulator GutR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL	637012..682044	45032

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (113-225)

Sequences

Toxin

Protein

• Length: 234 a.a.
• Molecular weight: 28030.81 Da
• Isoelectric Point: 6.7542

>T142734 WP_153952055.1 NZ_CP045825:680588-681289 [Bacillus subtilis]
MIKCTCEIESFCNDLHELILEINQLHNDFSTEFSLNKDVKHFNLRKKQIRHITEVTQKKGLFSIDNDFFILLQHYAEKLE
DVVIYNDLEYLYSDFDLRLRVKQPDSIVNKLKYYRVGKLESGQIPLRKCLNDLLGMRITIDSFDHNNDCFQNICDLLMKQ
YRINCMDSSKGDYKAFHFYFYGESNTFFPWELQIWRTEDKEANNRSHQLHKQEYTNWASIYKNSTETSVEKKR

Nucleotide

• Length: 702 bp

>T142734 NZ_CP060849:c327612-327199 [Salmonella enterica]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGTCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CGCGCCAACACTGA

Antitoxin

Protein

• Length: 250 a.a.
• Molecular weight: 28779.98 Da
• Isoelectric Point: 6.0906

>AT142734 WP_153952056.1 NZ_CP045825:681295-682044 [Bacillus subtilis]
MAFHFIAIISDFSGGRRIGWHYSSEERLDKNYISEFFERVKEKCGKIQFGIHKLSTDSTSWNSVTEKDSFFDDVIVTEDI
TAFIDVISKDKELTAYDVAKFVLSLQPSSHLKLQKLLYYMYAEFLLKTGKKLFKEPIVAFKYGPVIEDIFFKYKVHGKSL
IDYQEDANIKLLTDDLVVTPSFMKVLSSEHGLEAIECITNVLIKYGKYAPFRLVDMTHQEGGPWQRAYEPGQNCVITDEL
ITQYHQYAT

Nucleotide

• Length: 750 bp

>AT142734 NZ_CP060849:c327859-327593 [Salmonella enterica]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA