Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 617473..618109 Replicon chromosome
Accession NZ_CP045814
Organism Bacillus licheniformis strain P8_B2

Toxin (Protein)


Gene name mazF Uniprot ID M5P3Q9
Locus tag GII88_RS03170 Protein ID WP_003179128.1
Coordinates 617759..618109 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID M5PDU2
Locus tag GII88_RS03165 Protein ID WP_006638778.1
Coordinates 617473..617754 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GII88_RS03145 612588..614069 + 1482 WP_009330132.1 PH domain-containing protein -
GII88_RS03150 614066..614665 - 600 WP_003179118.1 rhomboid family intramembrane serine protease -
GII88_RS03155 615008..615967 + 960 WP_152847888.1 outer membrane lipoprotein carrier protein LolA -
GII88_RS03160 616192..617361 + 1170 WP_026080763.1 alanine racemase -
GII88_RS03165 617473..617754 + 282 WP_006638778.1 hypothetical protein Antitoxin
GII88_RS03170 617759..618109 + 351 WP_003179128.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
GII88_RS03175 618227..619054 + 828 WP_003179130.1 RsbT co-antagonist protein RsbRA -
GII88_RS03180 619058..619423 + 366 WP_003179132.1 STAS domain-containing protein -
GII88_RS03185 619426..619827 + 402 WP_003179135.1 anti-sigma regulatory factor -
GII88_RS03190 619838..620845 + 1008 WP_003179137.1 PP2C family protein-serine/threonine phosphatase -
GII88_RS03195 620904..621230 + 327 WP_003179140.1 anti-sigma factor antagonist -
GII88_RS03200 621230..621715 + 486 WP_003179142.1 anti-sigma B factor RsbW -
GII88_RS03205 621681..622472 + 792 WP_003179144.1 RNA polymerase sigma factor SigB -
GII88_RS03210 622469..623068 + 600 WP_003179145.1 SpoIIE family protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12990.03 Da        Isoelectric Point: 5.7234

>T142652 WP_003179128.1 NZ_CP045814:617759-618109 [Bacillus licheniformis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNNIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVNEALQISLALIDF

Download         Length: 351 bp

>T142652 NZ_CP060807:4167059-4167277 [Klebsiella variicola]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAACTGGCGGTATTTTACTCAGCCGCCGATCATCGTCTGGCTGAAC
TGACCATGAATAAGCTGTACGATAAGATCCCGACCTCAGTCTGGAAGTTTATCCGCTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10649.03 Da        Isoelectric Point: 4.6920

>AT142652 WP_006638778.1 NZ_CP045814:617473-617754 [Bacillus licheniformis]
MSESSATTEILIRLPEALVSELDGVVMQDNGSRNELIYQATKMYLRERKNRQIRESMRRGYMEMAKINLNISSEAQFAEY
EAENTVERLVSGG

Download         Length: 282 bp

>AT142652 NZ_CP060807:4166658-4167032 [Klebsiella variicola]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACTTCGGCTGTCAATCTTCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCGCTTAATTATAAAATTAAGTACACTGAGGATAATAAACTGGTCGCTCAGGTTGACGAATATCTG
GACGATACTTTTACCTTGTTCAGTAACTACGGCATTAACTCAACGGATTTGCAAAAGTGGAAAAAATCCGGTAATCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTCTCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I7FHI4

Antitoxin

Source ID Structure
AlphaFold DB M5PDU2

References