Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VapB
Location 2816998..2817614 Replicon chromosome
Accession NZ_CP045809
Organism Gordonia pseudamarae strain CON9

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GII31_RS12445 Protein ID WP_213243471.1
Coordinates 2817210..2817614 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GII31_RS12440 Protein ID WP_213243469.1
Coordinates 2816998..2817213 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GII31_RS12405 (GII31_12335) 2812068..2812340 - 273 WP_213243460.1 hypothetical protein -
GII31_RS12410 (GII31_12340) 2812723..2813781 - 1059 WP_260839960.1 AAA family ATPase -
GII31_RS12415 2813880..2814212 - 333 WP_260839961.1 hypothetical protein -
GII31_RS12420 (GII31_12345) 2814310..2814540 - 231 WP_213243463.1 helix-turn-helix domain-containing protein -
GII31_RS12425 (GII31_12350) 2814597..2815256 + 660 WP_213243465.1 hypothetical protein -
GII31_RS12430 (GII31_12355) 2815253..2816626 + 1374 WP_213243467.1 site-specific integrase -
GII31_RS12440 (GII31_12365) 2816998..2817213 + 216 WP_213243469.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
GII31_RS12445 (GII31_12370) 2817210..2817614 + 405 WP_213243471.1 PIN domain nuclease Toxin
GII31_RS12450 (GII31_12375) 2817668..2819107 - 1440 WP_213243473.1 ribosome biogenesis GTPase Der -
GII31_RS12455 (GII31_12380) 2819104..2819835 - 732 WP_246221848.1 (d)CMP kinase -
GII31_RS12460 (GII31_12385) 2819832..2820875 - 1044 WP_213243475.1 pseudouridine synthase -
GII31_RS12465 (GII31_12390) 2820885..2821571 - 687 WP_213250272.1 SMC-Scp complex subunit ScpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-121)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-38)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14906.07 Da        Isoelectric Point: 4.6805

>T142622 WP_213243471.1 NZ_CP045809:2817210-2817614 [Gordonia pseudamarae]
VILVDTSVWIEYLRDTDDPVVTELSSLIDSGADLRMTEPIAMELLAGADNPRRDALISQLTNSFPTLPVEPLVDYRAAAQ
IFASVRRIGHPLRSLNDCLIAAIAVRTSTILFERDRDFQFISKVTPLALHRNST

Download         Length: 405 bp

>T142622 NZ_CP060789:c3326100-3325786 [Tessaracoccus defluvii]
GTGCGTGAGATCTGCCTGGTCCGGCTCGACAAGACACGGCCAGCAGTCGTTCTGACTCGCGAGGCCGCGCGGGCGGCCAT
GACGAAAGTCACGATCGCGCCGATCACCTCCACCGTCAAGGGCCTGTCCAGCGAAGTCCCGGTCGGCCCTGCCAACGGCC
TCGACCACGACGGCGTGATCTCCCTCGACAACGTCGTCACCGTTCCGAGCAGGCTACTCGGGCGCACCGTCGGGTTTCTG
ACCCACGCACAGGAGGCCGAGCTCGCCCGGGCGGTCGTCCTGGCCTACGACCTCGATATCCCGTTGCTCGATTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8103.29 Da        Isoelectric Point: 5.8214

>AT142622 WP_213243469.1 NZ_CP045809:2816998-2817213 [Gordonia pseudamarae]
MTRTNIDLDDDLVAEVIKRFNVSTKKEAVDLALRRLVGVPLTTQFLHELRGIGWKGDLDELRAAEDPWKGR

Download         Length: 216 bp

>AT142622 NZ_CP060789:c3326337-3326104 [Tessaracoccus defluvii]
ATGAGCACGCAGATCGCGATCCGACTCCCAGACGACATGGTGGCCTTCCTGGACAAGTCCGTGGCGGCCGGCGACGCTCC
CAGCCGAGCAGCGCTGGTGGCTCGCGCGGTCGAGCGAGAGATGCGCCGCCAGGTTGCCGAGCAGGACGCCGTCATCCTCC
GCGAGCGGGGCACCGCTGACGATCTAGACGAGCTGGTCAACTGGTCCGTCGCACACACCACCGTCGAGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References