Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2929684..2930309 Replicon chromosome
Accession NZ_CP045808
Organism Gordonia amarae strain BEN368

Toxin (Protein)


Gene name vapC Uniprot ID G7GJ74
Locus tag GII32_RS13205 Protein ID WP_005181454.1
Coordinates 2929902..2930309 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G7GJ73
Locus tag GII32_RS13200 Protein ID WP_005181448.1
Coordinates 2929684..2929902 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GII32_RS13175 2925071..2925409 - 339 WP_040514001.1 integrase core domain-containing protein -
GII32_RS13180 (GII32_13095) 2925390..2926556 - 1167 WP_085949019.1 IS30 family transposase -
GII32_RS13185 (GII32_13100) 2926634..2927895 + 1262 Protein_2596 IS256 family transposase -
GII32_RS13190 (GII32_13105) 2927987..2928931 + 945 WP_244427206.1 Rpn family recombination-promoting nuclease/putative transposase -
GII32_RS13195 (GII32_13110) 2928993..2929592 + 600 WP_213263112.1 hypothetical protein -
GII32_RS13200 (GII32_13115) 2929684..2929902 + 219 WP_005181448.1 hypothetical protein Antitoxin
GII32_RS13205 (GII32_13120) 2929902..2930309 + 408 WP_005181454.1 PIN domain nuclease Toxin
GII32_RS13210 (GII32_13125) 2930314..2933649 + 3336 WP_005181457.1 DEAD/DEAH box helicase family protein -
GII32_RS13215 (GII32_13130) 2933679..2934755 - 1077 WP_005181458.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2925071..2938648 13577


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14715.60 Da        Isoelectric Point: 4.6025

>T142618 WP_005181454.1 NZ_CP045808:2929902-2930309 [Gordonia amarae]
MAWLVDKSALVRIAHSPDADQWQDRIARGLVHISSTTLLEVGFSARSASSWVELQNTPPVSDLPVESITPRTESRALEVQ
HALADRGTHRGPGPADLLIAAIAELSELTVLHVDKDFELIADITGQPMERLTGDF

Download         Length: 408 bp

>T142618 NZ_CP060789:c2023274-2022993 [Tessaracoccus defluvii]
GTGATCAGATCGTTCGGCGACAAGGCGACCGAACGGCTGTGGCGTCGTGAGCCCGTGCGATCGATCGATCCGAGGATCCA
GCGGGTTGCGCTGCGCAAGCTTCGTCAGGTGGGGTCTGCGGAGAGGCTCGACGATCTCCGGATCCCGCCAGGAAACCGAC
TTGAAGCGCTCAAGGGCGATCGAGCCGGTCAGTACAGCATCCGGATCAACGACCAGTGGAGGATCTGCTTCGTGTGGACC
GATGCTGGACCAGAGGAGGTGGAGATCGTTGACTATCACTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8189.20 Da        Isoelectric Point: 4.5291

>AT142618 WP_005181448.1 NZ_CP045808:2929684-2929902 [Gordonia amarae]
MTDILIRNVDDEVIARIDDQAQSLGMSRSEYLRQQLKTIAHPRGRTTRADLDRFSALAGDLLDDEVMAKAWD

Download         Length: 219 bp

>AT142618 NZ_CP060789:c2023006-2022704 [Tessaracoccus defluvii]
TTGACTATCACTGACAAGATTCCCCCGATTCACCCGGGCGAAGTCCTCATGGAGGACTTCATCGAGGGCTTCGGGATCAC
TCAGAACAAGCTCGCCGTCTCAATCGGAGTGCCACCACGCCGCATCAACGAGATCGTGCACGGCAAGAGGGGGATCACCG
CGGACACTGCGCTGCGGCTCGCGAAGTACTTCGGCACGTCGGCGGAGTTCTGGATCAACCTCCAGAGCCACTACGAGCTC
GACCGTGCAGAGGATCTTGCAGGTGAGCAGATCGCGTCGATCACACCGCTGAGCGTCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G7GJ74

Antitoxin

Source ID Structure
AlphaFold DB G7GJ73

References