Detailed information of TA system TA142617

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 2433326..2433960
• Replicon: chromosome
• Accession: NZ_CP045808
• Organism: Gordonia amarae strain BEN368

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: GII32_RS10925
• Protein ID: WP_211599611.1
• Coordinates: 2433586..2433960 (+)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A857MCV0
• Locus tag: GII32_RS10920
• Protein ID: WP_040514372.1
• Coordinates: 2433326..2433550 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GII32_RS10905 (GII32_10850)	2431138..2431392	+	255	WP_005183177.1	hypothetical protein	-
GII32_RS10910 (GII32_10855)	2431403..2432602	-	1200	WP_005183179.1	HipA domain-containing protein	-
GII32_RS10915 (GII32_10860)	2432599..2433225	-	627	WP_005183183.1	hypothetical protein	-
GII32_RS10920 (GII32_10865)	2433326..2433550	+	225	WP_040514372.1	hypothetical protein	Antitoxin
GII32_RS10925 (GII32_10870)	2433586..2433960	+	375	WP_211599611.1	PIN domain-containing protein	Toxin
GII32_RS10930 (GII32_10875)	2434052..2435071	-	1020	WP_005183190.1	beta-ketoacyl-ACP synthase III	-
GII32_RS10935 (GII32_10880)	2435239..2436135	+	897	WP_040514399.1	PHB depolymerase family esterase	-
GII32_RS10940 (GII32_10885)	2436226..2437692	+	1467	WP_005183196.1	carboxylesterase family protein	-
GII32_RS10945 (GII32_10890)	2437823..2438272	+	450	WP_005183199.1	hypothetical protein	-
GII32_RS10950 (GII32_10895)	2438331..2438861	+	531	WP_005183200.1	ABC-2 family transporter protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (11-111)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 13633.76 Da
• Isoelectric Point: 4.8892

>T142617 WP_211599611.1 NZ_CP045808:2433586-2433960 [Gordonia amarae]
MQMGQAARLDEWNARIERGLVRMSTVTRLELGFSVRSGESGRRAFVIPPLSLMPIEHLTPAMEDRAFEVQMMLADRGQHR
APSIPDLLIAATAEKLGLTVLAVDKDFDLIADITGQTVETLAST

Nucleotide

• Length: 375 bp

>T142617 NZ_CP060789:c2016641-2016351 [Tessaracoccus defluvii]
GTGAGCAACTACCGTCTCTCCCCAGCCGCGCAGCGCGACCTCTCGTCGATCTGGGACTCCACCGAGGAGCGCAGGGACAT
CCGCCAAGCAGAGACATATGTGACAGAGATCAGGTCTGCGATTGAACGTATCGCCGACGATCCTCGTCGCGGGCGCTCCT
GCGACGAGATCCGCGTCGGCTATCGGCGGTATGGCATTGGCAGCCACGCGCCTTTCTACGTCGAACGCGCCGGCGGCGTC
GACGTCATCCGGATTCTGCATCAACGGATGGACCCGACGAGGCACCTGTAA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8049.98 Da
• Isoelectric Point: 4.2264

>AT142617 WP_040514372.1 NZ_CP045808:2433326-2433550 [Gordonia amarae]
VTNVLIRGISEAAVERIDAEASALGLSRNEYLRRKLEGTAMVPTDVSVTAGDWQRSAETFADLADPDVMDAAWR

Nucleotide

• Length: 225 bp

>AT142617 NZ_CP060789:c2016871-2016638 [Tessaracoccus defluvii]
ATGGCGCAGAACACGTCGATCAGCTTGGATGATCACTTCACGGACTTCCTTTCCCGCGAGGTCTCGTCGGGTCGTTACCG
CTCCGCCAGCGAGGTCATCCGCGCCGGCCTCCGGCTCCTCGAGGACCAGGACACACGCTTGGGGGCTCTTCGTGCGGCTC
TGGTCGCGGGCGAGGAGAGCGGCGTGCCGGAAGAGTTCGACTTCGACGCCTTCATCGCCGCGAAGAAGTCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A857MCV0