Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2900806..2901431 Replicon chromosome
Accession NZ_CP045805
Organism Gordonia amarae strain BEN372

Toxin (Protein)


Gene name vapC Uniprot ID G7GJ74
Locus tag GII34_RS12995 Protein ID WP_005181454.1
Coordinates 2901024..2901431 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G7GJ73
Locus tag GII34_RS12990 Protein ID WP_005181448.1
Coordinates 2900806..2901024 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GII34_RS23540 2896193..2896531 - 339 WP_040514001.1 integrase core domain-containing protein -
GII34_RS12970 (GII34_12935) 2896512..2897678 - 1167 WP_085949019.1 IS30 family transposase -
GII34_RS12975 (GII34_12940) 2897756..2899017 + 1262 Protein_2562 IS256 family transposase -
GII34_RS12980 (GII34_12945) 2899109..2900053 + 945 WP_244427206.1 Rpn family recombination-promoting nuclease/putative transposase -
GII34_RS12985 (GII34_12950) 2900316..2900714 + 399 WP_005181446.1 hypothetical protein -
GII34_RS12990 (GII34_12955) 2900806..2901024 + 219 WP_005181448.1 hypothetical protein Antitoxin
GII34_RS12995 (GII34_12960) 2901024..2901431 + 408 WP_005181454.1 PIN domain nuclease Toxin
GII34_RS13000 (GII34_12965) 2901436..2904771 + 3336 WP_005181457.1 DEAD/DEAH box helicase family protein -
GII34_RS13005 (GII34_12970) 2904801..2905877 - 1077 WP_005181458.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14715.60 Da        Isoelectric Point: 4.6025

>T142610 WP_005181454.1 NZ_CP045805:2901024-2901431 [Gordonia amarae]
MAWLVDKSALVRIAHSPDADQWQDRIARGLVHISSTTLLEVGFSARSASSWVELQNTPPVSDLPVESITPRTESRALEVQ
HALADRGTHRGPGPADLLIAAIAELSELTVLHVDKDFELIADITGQPMERLTGDF

Download         Length: 408 bp

>T142610 NZ_CP060752:c21710-21360 [Escherichia coli]
ATGTGGGATATCATAACAACCGAGTGCTTTGATGGGTGGTTTCTTGCTCAGAGCGATGCTCTCAGGGAGTCTGTCTATGA
GGCTATGGGTGTACTGGAGAAATTCGGCCCGGCACTAGGTAGACCGTATGTTGATACGCTAAACGATTCTGATTTTGCCA
ATATGAAAGAGTTGCGCATCCAACATCATGGTAATCCTGTCAGAGCATTTTTTGCGTTTGATCCTACGCGCCGCGCCATC
GTCTTGTGTGCCGGTGATAAAACAGGGGCAAACGAAAAGCGCTTCTATAAGGATATGATTAGGCTTGCTGATTCGGAATA
CCGTAAACATCTTGCGAAACTGGAGAAATAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8189.20 Da        Isoelectric Point: 4.5291

>AT142610 WP_005181448.1 NZ_CP045805:2900806-2901024 [Gordonia amarae]
MTDILIRNVDDEVIARIDDQAQSLGMSRSEYLRQQLKTIAHPRGRTTRADLDRFSALAGDLLDDEVMAKAWD

Download         Length: 219 bp

>AT142610 NZ_CP060752:c21357-21058 [Escherichia coli]
ATGGCTACTTACAGAGAACTCCTGGCTAAAGAAAGCCCTGAAATGCAGGCTAGGGTAGCGGAGCGGGTTGAAGAAGTCAG
CATTCAAATAGCTCTTAGCATGTTACGTGATGAGCTAAATATTTCACAAACTGAGCTGGCTGCTGTCATGGGTGTTAAAC
AACCTTCTGTTGCCCGTATGGAGCAGGCTGACAATGATCCGAGACTATCAACACTCAAACGTTACGTGAAAGCGTTAGGT
GGAGAATTGAGTTTGGATGTAACACTTCCGACTGGTAAGCGAGTTGCATTTCATATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G7GJ74

Antitoxin

Source ID Structure
AlphaFold DB G7GJ73

References