Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2900806..2901431 Replicon chromosome
Accession NZ_CP045805
Organism Gordonia amarae strain BEN372

Toxin (Protein)


Gene name vapC Uniprot ID G7GJ74
Locus tag GII34_RS12995 Protein ID WP_005181454.1
Coordinates 2901024..2901431 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G7GJ73
Locus tag GII34_RS12990 Protein ID WP_005181448.1
Coordinates 2900806..2901024 (+) Length 73 a.a.

Genomic Context

GII34_RS12975GII34_RS12980GII34_RS12985GII34_RS12990GII34_RS12995GII34_RS13000GII34_RS23540GII34_RS12970GII34_RS13005
Location: 2897756..2899017 (1262 bp)
Type: Others
Protein ID: Protein_2562
Location: 2899109..2900053 (945 bp)
Type: Others
Protein ID: WP_244427206.1
Location: 2900316..2900714 (399 bp)
Type: Others
Protein ID: WP_005181446.1
Location: 2900806..2901024 (219 bp)
Type: Antitoxin
Protein ID: WP_005181448.1
Location: 2901024..2901431 (408 bp)
Type: Toxin
Protein ID: WP_005181454.1
Location: 2901436..2904771 (3336 bp)
Type: Others
Protein ID: WP_005181457.1
Location: 2896193..2896531 (339 bp)
Type: Others
Protein ID: WP_040514001.1
Location: 2896512..2897678 (1167 bp)
Type: Others
Protein ID: WP_085949019.1
Location: 2904801..2905877 (1077 bp)
Type: Others
Protein ID: WP_005181458.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GII34_RS235402896193..2896531-339WP_040514001.1integrase core domain-containing protein-
GII34_RS12970 (GII34_12935)2896512..2897678-1167WP_085949019.1IS30 family transposase-
GII34_RS12975 (GII34_12940)2897756..2899017+1262Protein_2562IS256 family transposase-
GII34_RS12980 (GII34_12945)2899109..2900053+945WP_244427206.1Rpn family recombination-promoting nuclease/putative transposase-
GII34_RS12985 (GII34_12950)2900316..2900714+399WP_005181446.1hypothetical protein-
GII34_RS12990 (GII34_12955)2900806..2901024+219WP_005181448.1hypothetical proteinAntitoxin
GII34_RS12995 (GII34_12960)2901024..2901431+408WP_005181454.1PIN domain nucleaseToxin
GII34_RS13000 (GII34_12965)2901436..2904771+3336WP_005181457.1DEAD/DEAH box helicase family protein-
GII34_RS13005 (GII34_12970)2904801..2905877-1077WP_005181458.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14715.60 Da        Isoelectric Point: 4.6025

>T142610 WP_005181454.1 NZ_CP045805:2901024-2901431 [Gordonia amarae]
MAWLVDKSALVRIAHSPDADQWQDRIARGLVHISSTTLLEVGFSARSASSWVELQNTPPVSDLPVESITPRTESRALEVQ
HALADRGTHRGPGPADLLIAAIAELSELTVLHVDKDFELIADITGQPMERLTGDF

Download         Length: 408 bp

>T142610 NZ_CP060752:c21710-21360 [Escherichia coli]
ATGTGGGATATCATAACAACCGAGTGCTTTGATGGGTGGTTTCTTGCTCAGAGCGATGCTCTCAGGGAGTCTGTCTATGA
GGCTATGGGTGTACTGGAGAAATTCGGCCCGGCACTAGGTAGACCGTATGTTGATACGCTAAACGATTCTGATTTTGCCA
ATATGAAAGAGTTGCGCATCCAACATCATGGTAATCCTGTCAGAGCATTTTTTGCGTTTGATCCTACGCGCCGCGCCATC
GTCTTGTGTGCCGGTGATAAAACAGGGGCAAACGAAAAGCGCTTCTATAAGGATATGATTAGGCTTGCTGATTCGGAATA
CCGTAAACATCTTGCGAAACTGGAGAAATAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8189.20 Da        Isoelectric Point: 4.5291

>AT142610 WP_005181448.1 NZ_CP045805:2900806-2901024 [Gordonia amarae]
MTDILIRNVDDEVIARIDDQAQSLGMSRSEYLRQQLKTIAHPRGRTTRADLDRFSALAGDLLDDEVMAKAWD

Download         Length: 219 bp

>AT142610 NZ_CP060752:c21357-21058 [Escherichia coli]
ATGGCTACTTACAGAGAACTCCTGGCTAAAGAAAGCCCTGAAATGCAGGCTAGGGTAGCGGAGCGGGTTGAAGAAGTCAG
CATTCAAATAGCTCTTAGCATGTTACGTGATGAGCTAAATATTTCACAAACTGAGCTGGCTGCTGTCATGGGTGTTAAAC
AACCTTCTGTTGCCCGTATGGAGCAGGCTGACAATGATCCGAGACTATCAACACTCAAACGTTACGTGAAAGCGTTAGGT
GGAGAATTGAGTTTGGATGTAACACTTCCGACTGGTAAGCGAGTTGCATTTCATATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBG7GJ74

Antitoxin

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Source
ID
Structure
AlphaFold DBG7GJ73

References