Detailed information of TA system TA142609

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 2401868..2402502
• Replicon: chromosome
• Accession: NZ_CP045805
• Organism: Gordonia amarae strain BEN372

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: GII34_RS10725
• Protein ID: WP_211599611.1
• Coordinates: 2402128..2402502 (+)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A857MCV0
• Locus tag: GII34_RS10720
• Protein ID: WP_040514372.1
• Coordinates: 2401868..2402092 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GII34_RS10705 (GII34_10675)	2399680..2399934	+	255	WP_005183177.1	hypothetical protein	-
GII34_RS10710 (GII34_10680)	2399945..2401144	-	1200	WP_005183179.1	HipA domain-containing protein	-
GII34_RS10715 (GII34_10685)	2401141..2401767	-	627	WP_005183183.1	hypothetical protein	-
GII34_RS10720 (GII34_10690)	2401868..2402092	+	225	WP_040514372.1	hypothetical protein	Antitoxin
GII34_RS10725 (GII34_10695)	2402128..2402502	+	375	WP_211599611.1	PIN domain-containing protein	Toxin
GII34_RS10730 (GII34_10700)	2402594..2403613	-	1020	WP_005183190.1	beta-ketoacyl-ACP synthase III	-
GII34_RS10735 (GII34_10705)	2403781..2404677	+	897	WP_040514399.1	PHB depolymerase family esterase	-
GII34_RS10740 (GII34_10710)	2404768..2406234	+	1467	WP_005183196.1	carboxylesterase family protein	-
GII34_RS10745 (GII34_10715)	2406365..2406814	+	450	WP_005183199.1	hypothetical protein	-
GII34_RS10750 (GII34_10720)	2406873..2407403	+	531	WP_005183200.1	ABC-2 family transporter protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (11-111)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 13633.76 Da
• Isoelectric Point: 4.8892

>T142609 WP_211599611.1 NZ_CP045805:2402128-2402502 [Gordonia amarae]
MQMGQAARLDEWNARIERGLVRMSTVTRLELGFSVRSGESGRRAFVIPPLSLMPIEHLTPAMEDRAFEVQMMLADRGQHR
APSIPDLLIAATAEKLGLTVLAVDKDFDLIADITGQTVETLAST

Nucleotide

• Length: 375 bp

>T142609 NZ_CP060751:c65739-65323 [Escherichia coli]
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAGCCGTCCTGAAGCGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTAACGAATAATACAAGAGAATTTGAGCGAGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8049.98 Da
• Isoelectric Point: 4.2264

>AT142609 WP_040514372.1 NZ_CP045805:2401868-2402092 [Gordonia amarae]
VTNVLIRGISEAAVERIDAEASALGLSRNEYLRRKLEGTAMVPTDVSVTAGDWQRSAETFADLADPDVMDAAWR

Nucleotide

• Length: 225 bp

>AT142609 NZ_CP060751:c65966-65736 [Escherichia coli]
ATGAGAACCGTATCGATATTCAAAAATGGCAACAACCGCGCCATCCGTCTGCCTCGTGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCAACCTGGGGATCATTCCTAGAGTACG
AAAAAGCCGATCCAGATTTTATGGCGGAGCGCGAGGATGTTGTCAGCGACGAAGGGCGATTTAACCTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A857MCV0