Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2938441..2939066 Replicon chromosome
Accession NZ_CP045804
Organism Gordonia amarae strain BEN374

Toxin (Protein)


Gene name vapC Uniprot ID G7GJ74
Locus tag GII35_RS13200 Protein ID WP_005181454.1
Coordinates 2938659..2939066 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G7GJ73
Locus tag GII35_RS13195 Protein ID WP_005181448.1
Coordinates 2938441..2938659 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GII35_RS24120 2933828..2934166 - 339 WP_040514001.1 integrase core domain-containing protein -
GII35_RS13175 (GII35_13140) 2934147..2935313 - 1167 WP_085949019.1 IS30 family transposase -
GII35_RS13180 (GII35_13145) 2935391..2936652 + 1262 Protein_2606 IS256 family transposase -
GII35_RS13185 (GII35_13150) 2936744..2937688 + 945 WP_244427206.1 Rpn family recombination-promoting nuclease/putative transposase -
GII35_RS13190 (GII35_13155) 2937750..2938349 + 600 WP_213263112.1 hypothetical protein -
GII35_RS13195 (GII35_13160) 2938441..2938659 + 219 WP_005181448.1 hypothetical protein Antitoxin
GII35_RS13200 (GII35_13165) 2938659..2939066 + 408 WP_005181454.1 PIN domain nuclease Toxin
GII35_RS13205 (GII35_13170) 2939071..2942406 + 3336 WP_005181457.1 DEAD/DEAH box helicase family protein -
GII35_RS13210 (GII35_13175) 2942436..2943512 - 1077 WP_005181458.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14715.60 Da        Isoelectric Point: 4.6025

>T142608 WP_005181454.1 NZ_CP045804:2938659-2939066 [Gordonia amarae]
MAWLVDKSALVRIAHSPDADQWQDRIARGLVHISSTTLLEVGFSARSASSWVELQNTPPVSDLPVESITPRTESRALEVQ
HALADRGTHRGPGPADLLIAAIAELSELTVLHVDKDFELIADITGQPMERLTGDF

Download         Length: 408 bp

>T142608 NZ_CP060750:126391-126678 [Escherichia coli]
ATGACTTATACAGTAAAATTCCGGGATGATGCACTGAAAGAATGGCTCAGACTGGACAAGACCATTCAGCAGCAGTTCGC
AAAAAAACTGAAAAAATGCAGTGAAAATCCTCATATAGCTTCTGCAAAACTACGTGGATTAAAGGACTGCTATAAAATCA
AACTTCGCGCATCAGGTTTTCGTCTGGTTTATCAGGTTATTGATGATATGTTAATTATTGCGGTCGTCGCAGTAGGTAAA
CGTGAACGCAGCAACGTTTATCATCTCGCCAGTGAACGGATGAAATAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8189.20 Da        Isoelectric Point: 4.5291

>AT142608 WP_005181448.1 NZ_CP045804:2938441-2938659 [Gordonia amarae]
MTDILIRNVDDEVIARIDDQAQSLGMSRSEYLRQQLKTIAHPRGRTTRADLDRFSALAGDLLDDEVMAKAWD

Download         Length: 219 bp

>AT142608 NZ_CP060750:126143-126394 [Escherichia coli]
ATGCCCAGTATCATTTTGTCTGACACCAGTGCAAGCGTCAGTGAGCTGAAAAAAAATCCGATGGCAACTGTCAGTGCCGG
AGAGGGGTATCCTGTTGCCATTCTTAACCGGAATCAGCCAGCATTCTACTGTGTCCCTGCTGAGCTCTATGAAAGAATGC
TTGATGCCTTGGATGACCAGGAGCTGGTAAAACTGGTTACTGAACGCAGCAGTCAGCCTCTGCATGATGTGGACCTGGAC
AGTTATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G7GJ74

Antitoxin

Source ID Structure
AlphaFold DB G7GJ73

References