Detailed information of TA system TA142607

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 2442046..2442680
• Replicon: chromosome
• Accession: NZ_CP045804
• Organism: Gordonia amarae strain BEN374

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: GII35_RS10945
• Protein ID: WP_211599611.1
• Coordinates: 2442306..2442680 (+)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A857MCV0
• Locus tag: GII35_RS10940
• Protein ID: WP_040514372.1
• Coordinates: 2442046..2442270 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GII35_RS10925 (GII35_10895)	2439858..2440112	+	255	WP_005183177.1	hypothetical protein	-
GII35_RS10930 (GII35_10900)	2440123..2441322	-	1200	WP_005183179.1	HipA domain-containing protein	-
GII35_RS10935 (GII35_10905)	2441319..2441945	-	627	WP_005183183.1	hypothetical protein	-
GII35_RS10940 (GII35_10910)	2442046..2442270	+	225	WP_040514372.1	hypothetical protein	Antitoxin
GII35_RS10945 (GII35_10915)	2442306..2442680	+	375	WP_211599611.1	PIN domain-containing protein	Toxin
GII35_RS10950 (GII35_10920)	2442772..2443791	-	1020	WP_005183190.1	beta-ketoacyl-ACP synthase III	-
GII35_RS10955 (GII35_10925)	2443959..2444855	+	897	WP_040514399.1	PHB depolymerase family esterase	-
GII35_RS10960 (GII35_10930)	2444946..2446412	+	1467	WP_005183196.1	carboxylesterase family protein	-
GII35_RS10965 (GII35_10935)	2446543..2446992	+	450	WP_005183199.1	hypothetical protein	-
GII35_RS10970 (GII35_10940)	2447051..2447581	+	531	WP_005183200.1	ABC-2 family transporter protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (11-111)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 13633.76 Da
• Isoelectric Point: 4.8892

>T142607 WP_211599611.1 NZ_CP045804:2442306-2442680 [Gordonia amarae]
MQMGQAARLDEWNARIERGLVRMSTVTRLELGFSVRSGESGRRAFVIPPLSLMPIEHLTPAMEDRAFEVQMMLADRGQHR
APSIPDLLIAATAEKLGLTVLAVDKDFDLIADITGQTVETLAST

Nucleotide

• Length: 375 bp

>T142607 NZ_CP060750:c37539-37159 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTGATAGCGCTTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCTGGCATGTC
AGATCCGGGCAGGGCAGAGGCCATTATCGGGAGAGTCCAGGCCAGAGTTGTGTACGAAGAGATTACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGCTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACTGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCCGCGGAGTAG

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8049.98 Da
• Isoelectric Point: 4.2264

>AT142607 WP_040514372.1 NZ_CP045804:2442046-2442270 [Gordonia amarae]
VTNVLIRGISEAAVERIDAEASALGLSRNEYLRRKLEGTAMVPTDVSVTAGDWQRSAETFADLADPDVMDAAWR

Nucleotide

• Length: 225 bp

>AT142607 NZ_CP060750:c37760-37539 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Structures

Antitoxin

• AlphaFold DB: A0A857MCV0