Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2442046..2442680 Replicon chromosome
Accession NZ_CP045804
Organism Gordonia amarae strain BEN374

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GII35_RS10945 Protein ID WP_211599611.1
Coordinates 2442306..2442680 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A857MCV0
Locus tag GII35_RS10940 Protein ID WP_040514372.1
Coordinates 2442046..2442270 (+) Length 75 a.a.

Genomic Context

GII35_RS10925GII35_RS10940GII35_RS10945GII35_RS10955GII35_RS10960GII35_RS10965GII35_RS10970GII35_RS10930GII35_RS10935GII35_RS10950
Location: 2439858..2440112 (255 bp)
Type: Others
Protein ID: WP_005183177.1
Location: 2442046..2442270 (225 bp)
Type: Antitoxin
Protein ID: WP_040514372.1
Location: 2442306..2442680 (375 bp)
Type: Toxin
Protein ID: WP_211599611.1
Location: 2443959..2444855 (897 bp)
Type: Others
Protein ID: WP_040514399.1
Location: 2444946..2446412 (1467 bp)
Type: Others
Protein ID: WP_005183196.1
Location: 2446543..2446992 (450 bp)
Type: Others
Protein ID: WP_005183199.1
Location: 2447051..2447581 (531 bp)
Type: Others
Protein ID: WP_005183200.1
Location: 2440123..2441322 (1200 bp)
Type: Others
Protein ID: WP_005183179.1
Location: 2441319..2441945 (627 bp)
Type: Others
Protein ID: WP_005183183.1
Location: 2442772..2443791 (1020 bp)
Type: Others
Protein ID: WP_005183190.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GII35_RS10925 (GII35_10895)2439858..2440112+255WP_005183177.1hypothetical protein-
GII35_RS10930 (GII35_10900)2440123..2441322-1200WP_005183179.1HipA domain-containing protein-
GII35_RS10935 (GII35_10905)2441319..2441945-627WP_005183183.1hypothetical protein-
GII35_RS10940 (GII35_10910)2442046..2442270+225WP_040514372.1hypothetical proteinAntitoxin
GII35_RS10945 (GII35_10915)2442306..2442680+375WP_211599611.1PIN domain-containing proteinToxin
GII35_RS10950 (GII35_10920)2442772..2443791-1020WP_005183190.1beta-ketoacyl-ACP synthase III-
GII35_RS10955 (GII35_10925)2443959..2444855+897WP_040514399.1PHB depolymerase family esterase-
GII35_RS10960 (GII35_10930)2444946..2446412+1467WP_005183196.1carboxylesterase family protein-
GII35_RS10965 (GII35_10935)2446543..2446992+450WP_005183199.1hypothetical protein-
GII35_RS10970 (GII35_10940)2447051..2447581+531WP_005183200.1ABC-2 family transporter protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(11-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13633.76 Da        Isoelectric Point: 4.8892

>T142607 WP_211599611.1 NZ_CP045804:2442306-2442680 [Gordonia amarae]
MQMGQAARLDEWNARIERGLVRMSTVTRLELGFSVRSGESGRRAFVIPPLSLMPIEHLTPAMEDRAFEVQMMLADRGQHR
APSIPDLLIAATAEKLGLTVLAVDKDFDLIADITGQTVETLAST

Download         Length: 375 bp

>T142607 NZ_CP060750:c37539-37159 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTGATAGCGCTTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCTGGCATGTC
AGATCCGGGCAGGGCAGAGGCCATTATCGGGAGAGTCCAGGCCAGAGTTGTGTACGAAGAGATTACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGCTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACTGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCCGCGGAGTAG

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8049.98 Da        Isoelectric Point: 4.2264

>AT142607 WP_040514372.1 NZ_CP045804:2442046-2442270 [Gordonia amarae]
VTNVLIRGISEAAVERIDAEASALGLSRNEYLRRKLEGTAMVPTDVSVTAGDWQRSAETFADLADPDVMDAAWR

Download         Length: 225 bp

>AT142607 NZ_CP060750:c37760-37539 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A857MCV0

References