142606

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1607637..1608272 Replicon chromosome
Accession NZ_CP045802
Organism Paenibacillus sp. B01

Toxin (Protein)


Gene name mazF Uniprot ID A0A2N5N3G9
Locus tag GE073_RS06920 Protein ID WP_028600569.1
Coordinates 1607922..1608272 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2N5N3F8
Locus tag GE073_RS06915 Protein ID WP_028600570.1
Coordinates 1607637..1607918 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GE073_RS06900 1603121..1604479 - 1359 WP_028600573.1 extracellular solute-binding protein -
GE073_RS06905 1604972..1606101 + 1130 Protein_1346 outer membrane lipoprotein carrier protein LolA -
GE073_RS06910 1606264..1607454 + 1191 WP_153784692.1 alanine racemase -
GE073_RS06915 1607637..1607918 + 282 WP_028600570.1 ribbon-helix-helix protein, CopG family Antitoxin
GE073_RS06920 1607922..1608272 + 351 WP_028600569.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
GE073_RS06925 1608499..1609224 + 726 WP_028600568.1 SAF domain-containing protein -
GE073_RS06930 1609221..1610057 + 837 WP_153783124.1 hypothetical protein -
GE073_RS06935 1610054..1611460 + 1407 WP_101808754.1 Flp pilus assembly complex ATPase component TadA -
GE073_RS06940 1611510..1612394 + 885 WP_153784693.1 type II secretion system F family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12930.88 Da        Isoelectric Point: 5.1336

>T142606 WP_028600569.1 NZ_CP045802:1607922-1608272 [Paenibacillus sp. B01]
MIVKRGDVFFADLSPVVGSEQGGVRPVLVLQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKEHGFDRDSVILLEQI
RTIDKQRLTDKITHLDDEMMRHVDDALQISVGLIDF

Download         Length: 351 bp

>T142606 NZ_CP060749:51683-51964 [Escherichia coli]
ATGACCTATGAACTGGCTTTTGACCGCAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAGCTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATATCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCTGTTGGAAGA
AGGGAAAGCAGCGAAGTTTATCAGATTGCAGATATGCGCTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10689.35 Da        Isoelectric Point: 8.5543

>AT142606 WP_028600570.1 NZ_CP045802:1607637-1607918 [Paenibacillus sp. B01]
VANVQNTKRIMISIPDHLLEEVDGIVAKENSNRSEFIRQAMKLYLVERKKRQIRELMQRGYLEMAKINLNMASEAFQAEE
DADRALGRLVSGV

Download         Length: 282 bp

>AT142606 NZ_CP060749:51442-51693 [Escherichia coli]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N5N3G9

Antitoxin

Source ID Structure
AlphaFold DB A0A2N5N3F8

References